Neuroscience

Envigo offers a large collection of pre-developed genetically engineered neurological rat models including advanced disease research rat models including Parkinson’s, Alzheimers, and autism to name a few. Envigo is a leader in molecular and phenotypic services featuring extensive scientific expertise in customized study and assay design, numerous in life and end point measurements, and study flexibility with comprehensive scientific project management.

We are consistently and reliably available to partner with you on a scientific and personal level to design, execute, and deliver exactly what you need to achieve and exceed your research and development goals.

Genetically engineered models (GEMs)

Rat Model	Specific Disease/Biological Function	Therapeutic Area
5Ht3a-Cre	Cre Tool for conditional expession or deletion in 5HT3a+ neurons	Neuroscience, Optogenetics
Alpha-Synuclein A53T SNCA KI Alpha-Synuclein SNCA KO	帕金森病	Neuroscience
ApoE KO	Alzheimer's disease	Neuroscience, Cardiovascular
App KO	Alzheimer's disease	Neuroscience
Bcrp KO	Drug metabolism, Transporter	ADMET, Neuroscience
BDNF KO	Alzheimer's disease, Schizophrenia, Huntington's disease	Neuroscience
Cacna1c KO	Autism (ASD)	Neuroscience
CamKIIa-Cre	Cre Tool for conditional expession or deletion in CamKIIa+ neurons	Neuroscience, Optogenetics
CHD8 KO	Autism (ASD)	Neuroscience
Chrna7 KO	Epilepsy, Schizophrenia	Neuroscience
Cntnap2 KO	Autism (ASD)	Neuroscience
Disc1 KO	Schizophrenia	Neuroscience
Dopamine Transporter (DAT)-Cre	Cre Tool for conditional expession or deletion in dopaminergic neurons	Neuroscience, Optogenetics
Faah KO	Pain	Neuroscience
Fmr1 KO	Autism (ASD), Fragile X syndrome	Neuroscience
Gabrb3	Autism (ASD), Epilepsy, Prader-Willi	Neuroscience
hApoe2 Knock-In hApoe3 Knock-In hApoE4 Knock-In	Alzheimer's disease	Neuroscience
Lrrk1 KO Lrrk1-Lrrk2 KO Lrrk2 KO	帕金森病	Neuroscience
MeCP2 KO	Autism (ASD), Rett Syndrome	Neuroscience
Met KO	Autism (ASD)	Neuroscience
mGluR5 KO	Autism (ASD), Fragile X syndrome, Schizophrenia	Neuroscience
Neurexin1 (Nrxn1) KO	Autism (ASD), Schizophrenia	Neuroscience
Neuroligin 3 (Nlgn3) KO	Asperger's syndrome, Autism (ASD)	Neuroscience
Oprm1 KO p75NTR KO	Pain	Neuroscience
Park2 Parkin KO Park7 DJ-1 KO	帕金森病	Neuroscience
Pde4b KO	Bipolar disorder, Schizophrenia	Neuroscience
Pink1 Park6 KO	帕金森病	Neuroscience
Pten KO	Autism (ASD), Oncology	Neuroscience, Oncology
Rbfox1 KO	Autism (ASD)	Neuroscience
Sst-Cre	Cre Tool for conditional expession or deletion in SST+ neurons	Neuroscience, Optogenetics
tdTomato Reporter	Optogenetics	Neuroscience
Tph2-Cre	Cre Tool for conditional expession or deletion in Tph2+ neurons	Neuroscience, Optogenetics
Trpv1 KO	Pain	Neuroscience
TH-Cre Vgat-Cre VIP-Cre	Cre Tool for conditional expession or deletion in Th+ neurons	Neuroscience, Optogenetics