Availability: Cryopreserved as homozygous embryos
Zygosity:Homozygous

This model contains a biallelic deletion of the organic anion transporter 1 (OAT1), also known as solute carrier family 22 member 6 (SLC22A6). Oat1 plays a central role in renal organic anion transport. Along with Oat3, Oat1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys- making this a useful model for studying drug-drug interations, toxicity and metabolism in the liver.