• Background strain: Sprague Dawley

Availability:李ve colony
Zygosity genotype:Homozygous

Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the endogenous rat SNCA gene, encoding the alpha-synuclein protein. This model was generated using the CRISPR/Cas9 genome targeting strategy. Mutations and multiplications of the SNCA gene have been linked to early-onset Parkinson’s disease (PD), making this model useful for understanding alpha-synuclein biology and PD pathogenesis.