• Biallelic 20 bp deletion within Nr1i2 gene
• Biallelic 10 bp deletion within Nr1i3 gene
• Biallelic 760 bp deletion within Ahr gene
• Background Strain: Sprague-Dawley

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

PXR, CAR, and AHR are involved in the induction of cytochrome p4503A (Cyp3a) and are abundantly expressed in the liver and intestine. This model is useful for studying metabolism of xenobiotic compounds and hepatotoxicity.

This triple knockout model was generated by crossing together the three single PXR, Car, and AHR knockout rat lines.