• Background strain: Sprague Dawley
• Copy number variations in Neurexin 1 have been linked to both ASD and schizophrenia
• Deletions in Neurexin 1 are present in ~0.5% of patients with ASD
• Neurexins are important for postsynaptic differentiation, especially so for GABA synaptic connections
• This model was created in collaboration with Autism Speaks and underwent phenotypic characterization by Dr. Richard Paylor.

Availability:冷冻保存作为杂合胚胎
Zygosity:Heterozygous

This model contains a biallelic deletion of the neuroligin 3 gene (Nlgn3). Mutations in Nlgn3 have been linked with autism and Asperger's syndrome. This model is useful for understanding the role of neuroligins in the development of autism spectrum disorders.

神经源素是与β新生素结合的神经元细胞 - 表面蛋白，跨越突出突触。神经源素可能在突触塑性中发挥作用，并且神经源素3中的突变与自闭症和患者综合征有关。