• 11 base pair deletion in exon 2
• Background strain: Sprague Dawley
• Early stop codon in exon 3

Availability:低温贮藏是杂合的胚胎
Zygosity:Heterozygous

This model contains a biallelic deletion of the Ngfr gene, encoding for the p75 neurotrophin receptor (p75NTR). Along with TrkA, p75NTR is a receptor for the nerve growth receptor and is important in nociception. The p75NTR knockout rat is useful for pain research.

NGF dysfunction has been linked to neuropathic and osteoarthritic pain along with hyperalgesia. Inhibition of NGF, including inhibition of the p75NTR, is being pursued as a potential analgesic.