• Background strain: Sprague Dawley
• Homozygous replacement of the Rat ApoE gene with the Human ApoE4 gene

Availability:Live colony
Zygosity genotype:Homozygous

Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Additionally, the 4 allele of ApoE (ApoE4) is a major risk factor for Alzheimer's disease (AD), with possession of at least one ApoE4 allele in 40-65% of patients with AD and a patient with 2 ApoE4 alleles having up to 20 times the risk of developing AD.

ApoE4 has been implicated in Alzheimer's disease and cognition, making this a useful model for the study of atherosclerosis, Alzheimer's and nerve injury.