• Background strain: Long Evans Hooded
• Cre recombinase driven by endogenous Paravalbumin promoter
• No observed ectopic expression of cre
• Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC

Availability:Live colony
Zygosity genotype:Homozygous

This model expresses cre-recombinase under the control of the endogenous paravalbumin (Pvalb) promoter enabling specific expression in inhibitory neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Pvalb. The Paravalbumin-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.