• Background strain: Long Evans Hooded
• Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
• Lrrk2 knockout rats are significantly larger than wild type controls
• Lrrk2 knockout rats display dark kidneys, similar to observations made in Lrrk2 knockout mice

Availability:Live colony
Zygosity genotype:Homozygous

Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2. Mutations in Lrrk2 are the most common monogenic cause of Parkinson's disease. This model is useful in understanding Lrrk2 biology.

Lrrk2 mutations account for 5-6% of familial Parkinson's dieases and 1-3% in sporadic PD. Collectively, these mutations result in the most common cause of PD, making this an important model for the study of Parkinson's disease.