CLOSE×

    Aging

    Krug A，WöhrM，Seffer D，Rppperger H，SungurAÖ，Dietsche B，Stein F，Sivalingam S，Forstner AJ，Witt Sh，Dukal H，Stev F，Maaser A，Heilmann-Heimbach S，Andlauer TFM，Herms S，Hoffmann P，Rietschel M，NöthenMM，Lickinger M，Schratt G，Koch M，Schwarting RKW，Kircher T.，Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study, Mol Autism. 2020 Jun 23;11(1):54. doi: 10.1186/s13229-020-00345-2.
    Marshall, Hayley J; Pezze, Marie A; Fone, Kevin C F; Cassaday, Helen J;,Age-related differences in appetitive trace conditioning and novel object recognition procedures.，学习和记忆的神经生物学Vol.164,2019
    Cabiati M, Salvadori C, Sapio A, Burchielli S, Carlucci L, Moscato S, Sabatino L, Caselli C, Mattii L, Del Ry S.,Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges，exp gerontol。2020年5月; 133：110879。DOI：10.1016 / J.Exger.2020.110879。EPUB 2020 2月17日。
    Rickard，R. F.，Engelbrecht，G. H.，＆Hudson，D。A.（2011）。，两种动脉微创术技术的实验研究，用于管理小于大于大直径差异的实验。, Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS, 64(8), 1088-1095. doi:10.1016/j.bjps.2011.03.011 [doi]
    Rickard, R. F., McPhaden, A. R., & Hudson, D. A. (2014),两种微观吻合直径不匹配的愈合, The Journal of Surgical Research, 191(1), 239-49.e3. doi:10.1016/j.jss.2014.03.011 [doi]
    Moscato S，Cabiati M，Bianchi F，Panetta D，Burchielli S，Massimetti G，Del Ry S，Mattii L.，与老化的第一阶段相关的心脏和肝connexin表达：对天然老年动物的研究，Acta组织。2020年12月122（8）：151651。DOI：10.1016 / J.Acthis.2020.151651。EPUB 2020 11月7日。
    Pereira GC, Lee L, Rawlings N, Ouwendijk J, Parker JE, Andrienko TN, Henley JM, Halestrap AP.,单独的六酮酶II解离不能考虑缺血后渗透性过渡孔隙开口的心脏线粒体功能，形态和敏感性的变化，plos一个。2020 Jun 24;15(6):e0234653. doi: 10.1371/journal.pone.0234653. eCollection 2020.
    Werkman Il，KövileinJ，De Jonge JC，Baron W.，Impairing committed cholesterol biosynthesis in white matter astrocytes, but not grey matter astrocytes, enhances in vitro myelination，J Neurochem。2020 6月30日.DOI：10.1111 / JNC.15113。在线之前在线。
    Anderton, M. J., Mellor, H. R., Bell, A., Sadler, C., Pass, M., Powell, S., . . . Heier, A. (2011).,小分子ALK5抑制剂诱导心脏瓣膜病变，毒理病理学，39（6），916-924。DOI：10.1177 / 0192623311416259 [DOI]
    Macdonald, D., Tessari, M. A., Boogaard, I., Smith, M., Pulli, K., Szynol, A., . . . Munoz-Sanjuan, I. (2014).,总量和聚谷氨酰胺 - 膨胀的亨廷蛋白的定量测定。, PloS One, 9(5), e96854. doi:10.1371/journal.pone.0096854 [doi]

    一般性研究

    Kalafateli，A.L.，Vallof，D.，＆Jerlhag，E。（2018），Activation of amylin receptors attenuates alcohol-mediated behaviours in rodents, Addiction Biology, doi:10.1111/adb.12603 [doi]
    Kalafateli, Aimilia Lydia; Vallöf, Daniel; Jerlhag, Elisabet;,Activation of amylin receptors attenuates alcohol-mediated behaviours in rodents, Addiction biology Vol.24, 2019
    Vestlund J, Bergquist F, Licheri V, Adermark L, Jerlhag E.,Activation of glucagon-like peptide-1 receptors and skilled reach foraging，瘾君子生物。2020 8月8日：E12953。DOI：10.1111 / adb.12953。在线之前在线。
    Lundberg, Stina; Högman, Cecilia; Roman, Erika;,Adolescent Exploratory Strategies and Behavioral Types in the Multivariate Concentric Square FieldTM Test., Frontiers in behavioral neuroscience Vol.13, 2019
    施耐德，P.，Bindila，L.，Schmahl，C.，Bohus，M.，Meyer-Lindenberg，A.，Lutz，B。。。。施耐德，M。（2016），青少年老鼠的不利社会经验导致对社会能力，疼痛敏感性和内炎素侧信号传导的持久影响。, Frontiers in Behavioral Neuroscience, 10, 203. doi:10.3389/fnbeh.2016.00203 [doi]
    Joekel de，Nur S，MonnéRodriguezJ，Kronenberg Pa，Kipar A，Leibundgut-Landmann S，P.，农林细胞增多症导致肠道棘球症多层血管间体间侵袭和肝脏元曲率发育在天然抗性Wistar大鼠, Parasitology. 2020 Oct 22:1-10. doi: 10.1017/S0031182020002012. Online ahead of print.
    Juschten J, Ingelse SA, Bos LDJ, Girbes ARJ, Juffermans NP, van der Poll T, Schultz MJ, Tuinman PR; BASIC study investigators.,Alkaline phosphatase in pulmonary inflammation-a translational study in ventilated critically ill patients and rats，密集护理Med Exp。2020年12月18日; 8（4）：46。DOI：10.1186 / s40635-020-00335-x。
    Lofténa，adermark l，ericson m，söderpalmb。，An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol's dopamine-releasing effect，瘾君子生物。2020 Aug 13:e12959. doi: 10.1111/adb.12959. Online ahead of print.
    Kalafateli, Aimilia Lydia; Vallöf, Daniel; Colombo, Giancarlo; Lorrai, Irene; Maccioni, Paola; Jerlhag, Elisabet;,淀粉蛋白类似物在醇类使用障碍的各种动物模型中衰减了与酒精相关的行为。神经咽部医生, official publication of the American College of Neuropsychopharmacology Vol.44, 2019
    Kalafateli Al，Satir TM，Vallöfd，Zetterberg H，Jerlhag E.，An amylin and calcitonin receptor agonist modulates alcohol behaviors by acting on reward-related areas in the brain，prog neurobiol。2020年12月2：101969。DOI：10.1016 / J.PNEUROBIO.2020.101969。在线之前在线。
    Nikam SP, Nettleton K, Everitt JI, Barton HA, Becker ML.,Antibiotic eluting poly(ester urea) films for control of a model cardiac implantable electronic device infection，Acta Biomater。2020年7月15日; 111：65-79。DOI：10.1016 / J.ACTBIO.2020.04.025。Epub 2020 5月22。
    Juschten, Jenny; Ingelse, Sarah Anne; Maas, Martinus Adrianus Wilhelmus; Girbes, Armand Roelof Johan; Juffermans, Nicole Petra; Schultz, Marcus Josephus; Tuinman, Pieter Roel;,抗凝血酶加α-1α-1蛋白酶抑制剂不会影响急性肺损伤的两种小鼠模型中的凝血和炎症。, Intensive care medicine experimental Vol.7, 2019
    Sherman, D., Oram, T., Harel, D., & Ahissar, E. (2017).,Attention robustly gates a closed-loop touch reflex, Current Biology : CB, 27(12), 1836-1843.e7. doi:S0960-9822(17)30624-3 [pii]
    Goepfrich，A. A.，Gluch，C.，Friemel，C. M.，＆Schneider，M。（2013）。，Behavioral differences in three wistar han rat lines for emotional reactivity, cognitive processing and ethanol intake., Physiology & Behavior, 110-111, 102-108. doi:10.1016/j.physbeh.2012.12.019 [doi]
    Parafati，M.，Lascala，A.，Morittu，V. M.，Trimboli，F.，Rizzuto，A.，Brunelli，E.，。。。Janda，E。（2015），Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome.，营养生物化学杂志，26（9），938-948。DOI：10.1016 / J.JNUTBIO.2015.03.008 [DOI]
    Lee SJ, Krieger JP, Vergara M, Quinn D, McDougle M, de Araujo A, Darling R, Zollinger B, Anderson S, Pan A, Simonnet EJ, Pignalosa A, Arnold M, Singh A, Langhans W, Raybould HE, de Lartigue G.,迷重的迷你可卡因和安非他明调节的转录物促进过双耳和体重增加，Cell Rep。2020 2月11日; 30（6）：2028-2039.E4。DOI：10.1016 / J.CELREP.2020.01.045。
    Vallöf, Daniel; Kalafateli, Aimilia Lydia; Jerlhag, Elisabet;,Brain region specific glucagon-like peptide-1 receptors regulate alcohol-induced behaviors in rodents, Psychoneuroendocrinology Vol.103, 2019
    Vallof, D., Ulenius, L., Egecioglu, E., Engel, J. A., & Jerlhag, E. (2017).,厌氧肽的中央疗法uGeuremedin U降低酒精摄入并衰减啮齿动物中的酒精诱导的奖励，成瘾生物学，22（3），640-651。DOI：10.1111 / adb.12355 [DOI]
    Rickard，R. F.，Wilson，J.，＆Hudson，D. A.（2009），大小差异（小到大）动脉微肿瘤研究啮齿动物模型的表征，实验动物，43（4），350-356。DOI：10.1258 / LA.2009.0080097 [DOI]
    Waeiss Ra，Knight CP，Engleman EA，Hauser SR，Rodd Za。，乙醇和尼古丁的共同施用对核毒剂（NAC）壳内的乙醇奖励的敏感性和增加的NAC壳BDNF足以增强NaïveWistar大鼠的乙醇奖励，J Neurochem。2020 Mar;152(5):556-569. doi: 10.1111/jnc.14914. Epub 2019 Dec 10.
    Harris SB, Hardisty JF, Hayes AW, Weber K.,Developmental and reproductive toxicity studies of BIA 10-2474，法调节毒药药物。2020 Mar;111:104543. doi: 10.1016/j.yrtph.2019.104543. Epub 2019 Nov 20.
    白色ar，werner cm，霍尔梅斯通用汽车。Diminished enteric neuromuscular transmission in the distal colon following experimental spinal cord injury, Exp Neurol. 2020 Sep;331:113377. doi: 10.1016/j.expneurol.2020.113377. Epub 2020 Jun 8.
    Salum，E.，Kampus，P.，Zilmer，M.，Eha，J.，Butlin，M.，Avolio，A.P.，。。。KALS，J.（2012）。，Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes, Cardiovascular Diabetology, 11, 58-2840-11-58. doi:10.1186/1475-2840-11-58 [doi]
    Kalafateli AL, Vestlund J, Raun K, Egecioglu E, Jerlhag E.,一种选择性长效淀粉受体激动剂对男性和女性大鼠醇消耗，食物摄入和体重的影响，瘾君子生物。2020 May 8:e12910. doi: 10.1111/adb.12910. Online ahead of print.
    Gines, I., Gil-Cardoso, K., Serrano, J., Casanova-Marti, A., Blay, M., Pinent, M., . . . Terra, X. (2018),间歇性葡萄种子原花青素（GSPE）治疗对大鼠自助式饮食溶性挑战的影响。，营养素，10（3），10.3390 / Nu10030315。DOI：E315 [PII]
    Fredriksson, I., Jayaram-Lindstrom, N., Wirf, M., Nylander, E., Nystrom, E., Jardemark, K., & Steensland, P. (2015),Evaluation of guanfacine as a potential medication for alcohol use disorder in long-term drinking rats: Behavioral and electrophysiological findings.，神经咽喉武装学：美国神经咽部学院的官方出版物，40（5），1130-1140。DOI：10.1038 / NPP.2014.294 [DOI]
    Wright，T. M.，Fone，K.C.，Langley-evans，S.C.，＆Voigt，J.P.（2011），Exposure to maternal consumption of cafeteria diet during the lactation period programmes feeding behaviour in the rat, International Journal of Developmental Neuroscience : The Official Journal of the International Society for Developmental Neuroscience, 29(8), 785-793. doi:10.1016/j.ijdevneu.2011.09.007 [doi]
    Schmitt MV, Reichel A, Liu X, Fricker G, Lienau P.,Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat, Drug Metab Dispos. 2021 Jan;49(1):53-61. doi: 10.1124/dmd.120.000161. Epub 2020 Nov 4.
    De Cuyper A, Winkler D, Tütken T, Janssens GPJ, Clauss M.,Fatty Acids of Microbial Origin in the Perirenal Fat of Rats (Rattus norvegicus domestica) and Guinea Pigs (Cavia porcellus) Fed Various Diets, Lipids. 2020 Jul;55(4):341-351. doi: 10.1002/lipd.12240. Epub 2020 Apr 28.
    Blankenship，B.，Eighmy，J. J.，Hoffmann，G.，Schroeder，M.，Sharma，A.K。，＆Sorden，S。（2016）。，Findings in historical control harlan RCCHan: WIST rats from 104-week oral gavage studies., Toxicologic Pathology, 44(7), 947-961. doi:10.1177/0192623316660768 [doi]
    布兰肯希普,B & Skaggs h .(2013)。在历史控制中的调查结果Harlan RCCHANTM：来自4-，13，26周的育种大鼠。, Toxicologic Pathology, 41(3), 537-547. doi:10.1177/0192623312460925 [doi]
    Gottschalk, M. G., Mortas, P., Haman, M., Ozcan, S., Biemans, B., & Bahn, S. (2018),Fluoxetine, not donepezil, reverses anhedonia, cognitive dysfunctions and hippocampal proteome changes during repeated social defeat exposure., European Neuropsychopharmacology : The Journal of the European College of Neuropsychopharmacology, 28(1), 195-210. doi:S0924-977X(17)31993-4 [pii]
    Miguéns-gómezA，Grau-Bovéc，塞拉克里斯M，Jorba-MartínR，Caro A，Rodríguez-Gallego E，Beltrán-debónr，blay mt，terra x，ardévola，pinent m.，来自昆虫的胃肠内消化的蛋白质来自昆虫毒素，刺激不同的肠暗肠，而不是牛肉或杏仁，在大鼠中产生差异反应, Nutrients. 2020 Aug 7;12(8):2366. doi: 10.3390/nu12082366.
    Vavers E，Zvejniece B，Stelfa G，Svalbe B，Vilks K，Kupats E，Mezapuke R，Lauberte L，Dambrova M，Zvejniece L.，Sigma-1伴侣蛋白的遗传失活导致GABA-B受体的R2亚基的表达降低，并增加了癫痫发作的易感性, Neurobiol Dis. 2020 Dec 30;150:105244. doi: 10.1016/j.nbd.2020.105244. Online ahead of print.
    Vestlund，Jesper;伯根金斯，菲利普;德尼尔·丹尼尔;瓦尔蒂娜，瓦尔蒂纳;adermark，路易斯;Jerlhag，Elisabet;Ghrelin signalling within the rat nucleus accumbens and skilled reach foraging., Psychoneuroendocrinology Vol.106, 2019
    Vallöf, Daniel; Vestlund, Jesper; Jerlhag, Elisabet;,Glucagon-like peptide-1 receptors within the nucleus of the solitary tract regulate alcohol-mediated behaviors in rodents.，神经药物博士学卷149,2019
    郑X，ariaseb，qi nr，saunders tl，cartee gd。，In vivo glucoregulation and tissue-specific glucose uptake in female Akt substrate 160 kDa knockout rats，plos一个。2020 2月13日; 15（2）：E0223340。DOI：10.1371 / journal.pone.0223340。ecollection 2020。
    Caceres，S.，Pena，L.，Moyano，G.，Martinez-Fernandez，L.，Monsalve，B.，Ilera，M.J.，。。。Silvan，G.（2015），Isoflavones and their effects on the onset of puberty in male wistar rats, Andrologia, doi:10.1111/and.12394 [doi]
    Vallöfd，卡拉法特利，杰尔哈格e。，用胰高血糖素的肽-1受体激动剂的长期治疗减少了男性和女性大鼠的乙醇摄入量, Transl Psychiatry. 2020 Jul 16;10(1):238. doi: 10.1038/s41398-020-00923-1.
    Houssari M，Dumesnil A，Tardif V，Kivelär，Pizzinat n，Boukhalfa I，Boyefroy D，Buefroy D，Schapman D，Hemanthakumar Ka，Bizou M，Henry JP，Renet S，Riou G，Rongeaux J，Anouar Y，Adriouch S，Fraine S，Alitalo K，Richard V，Mulder P，Brakenhielm E.，淋巴和免疫细胞串扰调节实验性心肌梗死后的心脏恢复，动脉段血栓血栓生物biol。2020年7020（7）：1722-1737。DOI：10.1161 / ATVBAHA.120.314370。Epub 2020 5月14。
    Wegner，W.，Burckhardt，B. C.，Burckhardt，G.，＆Henjakovic，M。（2012），Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6., PloS One, 7(4), e35556. doi:10.1371/journal.pone.0035556 [doi]
    卡林，加布里埃尔;Chaumontet，凯瑟琳;Blachier，François;巴比尔顿，皮埃尔;迪拉斯达科拉斯;Blais，Anne;Delteil，Corine;普里林，佛罗伦萨M;Blat，Sophie;van der beek，Eline M; Kodde, Andrea; Tomé, Daniel; Davila, Anne-Marie;,Maternal High-Protein Diet during Pregnancy Modifies Rat Offspring Body Weight and Insulin Signalling but Not Macronutrient Preference in Adulthood.，营养素第11卷，2019年
    Renko, J. M., Back, S., Voutilainen, M. H., Piepponen, T. P., Reenila, I., Saarma, M., & Tuominen, R. K. (2018).,Mesencephalic astrocyte-derived neurotrophic factor (MANF) elevates stimulus-evoked release of dopamine in freely-moving rats.，分子神经生物学，55（8），6755-6768。DOI：10.1007 / s12035-018-0872-8 [DOI]
    Segerstrom, L., Gustavsson, J., & Nylander, I. (2016).,通过热压台式组织稳定法最小化肽的后腔降解。, Biopreservation and Biobanking, 14(2), 172-179. doi:10.1089/bio.2015.0088 [doi]
    García-Magro N, Negredo P, Martin YB, Nuñez Á, Avendaño C.,通过刺激三叉神经病疼痛大鼠模型刺激术治疗复合物中机械感性振动反应的调节，j头痛疼痛。2020 8月6日; 21（1）：96。DOI：10.1186 / s10194-020-01161-y。
    Paasonen J，Laakso H，PirttimäkiT，Stenroos P，Salo Ra，Zhurakovskaya E，Lehto LJ，Tanila H，Garwood M，Michaeli S，Idiyatullin D，Mangia S，GröhnO.，多频带SWIFT在大鼠中启用安静和无瑕的EEG-FMRI和唤醒FMRI研究, Neuroimage. 2020 Feb 1;206:116338. doi: 10.1016/j.neuroimage.2019.116338. Epub 2019 Nov 12.
    Paasonen, Jaakko; Laakso, Hanne; Pirttimäki, Tiina; Stenroos, Petteri; Salo, Raimo A; Zhurakovskaya, Ekaterina; Lehto, Lauri J; Tanila, Heikki; Garwood, Michael; Michaeli, Shalom; Idiyatullin, Djaudat; Mangia, Silvia; Gröhn, Olli,多频带SWIFT在大鼠中启用安静和无瑕疵的EEG-FMRI和唤醒FMRI研究。，Neuroimage Vol.13,2019
    Onnheim, K., Ekblad, M., Gorander, S., Lange, S., Jennische, E., Bergstrom, T., . . . Liljeqvist, J. A. (2015).,Novel rat models to study primary genital herpes simplex virus-2 infection、档案of Virology, 160(5), 1153-1161. doi:10.1007/s00705-015-2365-7 [doi]
    MacDowell Ks，Martín-hernándezd，ulecia-morónc，BrisÁg，Madrigal JLM，García-Bueno B，Caso JR。，Paliperidone衰减慢性应激诱导的雄性大鼠常量皮层中炎症相关蛋白表达的变化, Int Immunopharmacol. 2020 Dec 4;90:107217. doi: 10.1016/j.intimp.2020.107217. Online ahead of print.
    Bjornsdottir, I., Sternebring, O., Kappers, W. A., Selvig, H., Korno, H. T., Kristensen, J. B., & Bagger, M. A. (2016),大鼠40kDA PEG和PEG化RFVIII（N8-GP）的药代动力学，组织分布和排泄，欧洲医药科学杂志：欧洲医药科学官方期刊，87,58-68。DOI：10.1016 / J.EJPS.2015.10.020 [DOI]
    kowash，h m;波特，H G;Edye，M e;普林森，e p;Bandinelli，S;Neill，J C;HAGER，R;玻璃玻璃，j d;，聚（i：c）源，分子量和内毒素污染影响水坝和产前结果，对母体免疫激活模型的影响，大脑，行为和免疫vol.82,2019
    Hermier, D., Mathe, V., Lan, A., Santini, C., Quignard-Boulange, A., Huneau, J. F., & Mariotti, F. (2017).,Postprandial low-grade inflammation does not specifically require TLR4 activation in the rat.，营养和新陈代谢，14,65-017-0220-4。2017年Ecollection。DOI：10.1186 / s12986-017-0220-4 [DOI]
    木，C.M.，Nicolas，C.，Choi，S.L.，罗马，E.，Nylander，I.，Fernandez-Teruel，A.，。。。Lodge，D。（2017）。，Prevalence and influence of cys407* Grm2 mutation in hannover-derived wistar rats: MGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour., Neuropharmacology, 115, 128-138. doi:S0028-3908(16)30092-2 [pii]
    Kokoshima, H., Doi, T., Yamada, N., & Tsuchitani, M. (2014).,Proliferative lesions in thyroid follicular cells of dwarfs derived from wistar hannover GALAS rats.，毒理病理学，42（3），565-572。DOI：10.1177 / 0192623313491858 [DOI]
    Karlsson, O., Segerstrom, L., Sjoback, R., Nylander, I., & Boren, M. (2016),基于QPCR的mRNA质量评分在热稳定后显示完整的mRNA, Biomolecular Detection and Quantification, 7, 21-26. doi:10.1016/j.bdq.2016.01.002 [doi]
    Wang, Xueying; Schmitt, Maximilian V; Xu, Lina; Jiao, Yupei; Guo, Lvjun; Lienau, Philip; Reichel, Andreas; Liu, Xiaohui,通过甲基化辅助高分辨率质谱法产生的双（单酰基甘油）磷酸盐和磷脂基甘油膜脂质的定量分子组织地图。, Analytica chimica acta Vol.1084, 2019
    Vilskersts R，Vilks K，Videja M，Cirule H，Zharkova-Malkova O，Sevostjanovs E，Dambrova M，LiePinsh E.，Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury, Physiol Rep. 2020 Nov;8(22):e14638. doi: 10.14814/phy2.14638.
    丁，Z.M.，Ingraham，C.M.，Hauser，S. R.，Lasek，A.W.，Bell，R.L.，＆McBride，W.J.（2017）。，预胶质皮层内的MgLu2受体水平降低与升高的谷氨酸透射或高级酒精饮用无关。, Alcoholism, Clinical and Experimental Research, 41(11), 1896-1906. doi:10.1111/acer.13488 [doi]
    Mitchard, T., & Stewart, J. (2014).,在使用Han Wistar RAT的初步调查中降低了产后人工产后与弯曲的长骨和肩胛骨前的发生率, Reproductive Toxicology (Elmsford, N.Y.), 45, 39-44. doi:10.1016/j.reprotox.2014.01.001 [doi]
    Willadsen，M.，Seffer，D.，Schwarting，R. K.，＆Wohr，M。（2014）。，啮齿动物超声通信：男性女性女性50 kHz超声波发声引发女性大鼠的社会方法行为（Rattus norvegicus）。, Journal of Comparative Psychology (Washington, D.C.: 1983), 128(1), 56-64. doi:10.1037/a0034778 [doi]
    MacDowell, K. S., Caso, J. R., Martin-Hernandez, D., Moreno, B. M., Madrigal, J. L. M., Mico, J. A., . . . Garcia-Bueno, B. (2016),非典型抗精神病药物酮调节大鼠急性和慢性约束胁迫的大鼠模型中的内源性抗氧化术。。神经治疗：美国实验神经治疗学杂志，13（4），833-843。DOI：10.1007 / s13311-016-0438-2 [DOI]
    Caceres, S., Silvan, G., Martinez-Fernandez, L., Illera, M. J., Millan, P., Monsalve, B., . . . Illera, J. C. (2014).,The effects of isoflavones on androgens and glucocorticoids during puberty on male wistar rats.，国内动物的繁殖= Zuchthygiene，49（4），611-617。DOI：10.1111 / RDA.12335 [DOI]
    Sanz-Lázaro，萨拉;Jiménez-Pompa，Amanda;Carmona-Hidalgo，Beatriz;Ubeda，María;贝诺兹，莱蒂西亚;Caba-González，何塞卡洛斯;Hernández-Vivanco，艾莉娅;萨奈·萨莱·佩斯 - 加西亚;Albillos，Agustín;almudena almudena;The firing frequency of spontaneous action potentials and their corresponding evoked exocytosis are increased in chromaffin cells of CCl4 -induced cirrhotic rats with respect to control rats, Journal of neurochemistry Vol.148, 2019
    Wright，T.，Langley-Evans，S.C.，＆Voigt，J.P.（2011）。，The impact of maternal cafeteria diet on anxiety-related behaviour and exploration in the offspring, Physiology & Behavior, 103(2), 164-172. doi:10.1016/j.physbeh.2011.01.008 [doi]
    Feltmann，K.，Fredriksson，I.，Wirf，M.，Schilstrom，B.，Steensland，P.（2016）。，The monoamine stabilizer (-)-OSU6162 counteracts downregulated dopamine output in the nucleus accumbens of long-term drinking wistar rats., Addiction Biology, 21(2), 438-449. doi:10.1111/adb.12304 [doi]
    Fredriksson，I.，Wirf，M.，＆Steensland，P.（2018）。，单胺稳定剂（ - ） - OSU6162可防止醇剥夺效果，提高大鼠的运动冲动行为。，成瘾生物学，DOI：10.1111 / adb.12613 [DOI]
    Treiber，A.，De Kanter，R.，Roch，C.，Gatfield，J.，Boss，C.，Von Raumer，M.。。。Jenck，F.（2017）。，The use of physiology-based pharmacokinetic and pharmacodynamic modeling in the discovery of the dual orexin receptor antagonist ACT-541468., The Journal of Pharmacology and Experimental Therapeutics, 362(3), 489-503. doi:10.1124/jpet.117.241596 [doi]
    Avila-Martin, G., Mata-Roig, M., Galan-Arriero, I., Taylor, J. S., Busquets, X., & Escriba, P. V. (2017).,用白蛋白 - 羟基酸复合物治疗脊髓损伤大鼠中的感觉传感器功能：疗效和基因表达调控。, PloS One, 12(12), e0189151. doi:10.1371/journal.pone.0189151 [doi]
    Arias, Edward B; Zheng, Xiaohua; Agrawal, Swati; Cartee, Gregory D;,全身葡糖和组织特异性葡萄糖摄取在160kDa敲除大鼠模型的新型AKT底物中，Plos一卷第14卷，2019

    Oncology

    Weber，K.，Garman，R.H.，Germann，P.G.，难以，J.F.，Krinke，G.，Millar，P.，＆Pardo，I。（2011）。，Classification of neural tumors in laboratory rodents, emphasizing the rat，毒理病理学，39（1），129-151。DOI：10.1177 / 0192623310392249 [DOI]
    Moilanen，A. M.，Riikonen，R.，Oksala，R.，Ravanti，L.，AHO，E.，Wohlfahrt，G.，。。。Kallio，P. J.（2015）。，Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies，科学报告，5,12007。DOI：10.1038 / SREP12007 [DOI]
    Moilanen，A. M.，Riikonen，R.，Oksala，R.，Ravanti，L.，AHO，E.，Wohlfahrt，G.，。。。Kallio，P. J.（2015）。，Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies.，科学报告，5,12007。DOI：10.1038 / SREP12007 [DOI]
    Keiler，A. M.，Macejova，D.，Dietz，B. M.，Bolton，J.L，Pauli，G. F.，Chen，S. N.，。。。Vollmer，G.（2017）。，标准化啤酒花提取物对乳腺生物学和MNU诱导乳腺肿瘤生长的标准化啤酒花提取物的雌激素效力评价。，类固醇生物化学和分子生物学，174,234-241。DOI：S0960-0760（17）30268-6 [PII]
    Rivera-Huerta，M.，Lizarraga-Grimes，V.L。，Castro-Torres，I. G.，Tinoco-Mendez，M.，Macias-Rosales，L.，Sanchez-Bartez，F.，。。。Gracia-mora，M. I.（2017），益生元叶片在动物模型中结肠癌和钙代谢的功能作用, BioMed Research International, 2017, 9758982. doi:10.1155/2017/9758982 [doi]
    Bradley, A. E., & Keane, K. (2011).,神经科学, Toxicologic Pathology, 39(1), 124-128. doi:10.1177/0192623310389477 [doi]
    Bolli, M. H., Abele, S., Birker, M., Bravo, R., Bur, D., de Kanter, R., . . . Weller, T. (2014).,Novel S1P(1) receptor agonists--part 3: From thiophenes to pyridines, Journal of Medicinal Chemistry, 57(1), 110-130. doi:10.1021/jm4014696 [doi]
    EMPL，M.T.，Kammeyer，P.，Ulrich，R.，Joseph，J.F.，Parr，M. K.，Willenberg，I.，。。。Steinberg，P。（2014），慢性L-肉碱补充对雄性F344大鼠结肠癌促塑料和动脉粥样硬化损伤的影响。、档案of Toxicology, doi:10.1007/s00204-014-1341-4 [doi]
    Colli-Dula，R.C.，弗里德曼，M. A.，汉森，B.，＆Denslow，N. D.（2016），Transcriptomics analysis and hormonal changes of male and female neonatal rats treated chronically with a low dose of acrylamide in their drinking water., Toxicology Reports, 3, 414-426. doi:10.1016/j.toxrep.2016.03.009 [doi]
    Maronpot，R. R.，Thoolen，R.J.，＆Hansen，B。（2015）。，Two-year carcinogenicity study of acrylamide in wistar han rats with in utero exposure.，实验性和毒性病理学：官方杂志的Gesellschaft毛皮Toxikologische Pathologie，67（2），189-195。DOI：10.1016 / J.ETP.2014.11.009 [DOI]
    Maronpot, R. R., Thoolen, R. J., & Hansen, B. (2015),Two-year carcinogenicity study of acrylamide in wistar han rats with in utero exposure.，实验性和毒性病理学：官方杂志的Gesellschaft毛皮Toxikologische Pathologie，67（2），189-195。DOI：10.1016 / J.ETP.2014.11.009 [DOI]

    teratology

    Devonshire, I. M., Preston, M. J., Dommett, E. J., Murphy, K. L., & Greenfield, S. A. (2009),低成本呼吸监测装置与麻醉毒性的低成本呼吸监测装置的设计与评价, Laboratory Animals, 43(4), 382-389. doi:10.1258/la.2009.0080124 [doi]
    Agterberg, M. J., Spoelstra, E. N., van der Wijst, S., Brakkee, J. H., Wiegant, V. M., Hamelink, R., . . . Remie, R. (2010),Evaluation of temperature rise and bonding strength in cements used for permanent head attachments in rats and mice, Laboratory Animals, 44(3), 264-270. doi:10.1258/la.2010.009083 [doi]
    克拉克,r·L。爱德华兹,t·L。隆戈,M, Kinney, J。, Walker, D. K., Rhodes, J., . . . Huber, A. C. (2018).,Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate，出生缺陷研究，110（7），553-578。DOI：10.1002 / BDR2.1170 [DOI]

    毒理学

    Lina, B. A., Messinger, H., & Bar, A. (2015).,13-week oral toxicity study of vinyl laurate in rats., Regulatory Toxicology and Pharmacology : RTP, 71(1), 101-107. doi:10.1016/j.yrtph.2014.10.015 [doi]
    Bartnikas, T. B., Wildt, S. J., Wineinger, A. E., Schmitz-Abe, K., Markianos, K., Cooper, D. M., & Fleming, M. D. (2013).,A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2.，比较医学，63（2），143-155。
    Grandy, T. H., Greenfield, S. A., & Devonshire, I. M. (2012).,An evaluation of in vivo voltage-sensitive dyes: Pharmacological side effects and signal-to-noise ratios after effective removal of brain-pulsation artifacts., Journal of Neurophysiology, 108(11), 2931-2945. doi:10.1152/jn.00512.2011 [doi]
    Salum，E.，Butlin，M.，KALS，J.，Zilmer，M.，EHA，J.，Avolio，A.P。，。。。Kampus，P。（2014），血管紧张素II受体阻滞剂Telmisartan衰减STZ-糖尿病大鼠的主动脉加强和重塑，糖尿病学和代谢综合征，6,57-5996-6-57。Ecollection 2014. DOI：10.1186 / 1758-5996-6-57 [DOI]
    Turpin，P. E.，Burnett，J. E.，Goodwin，L.，Foster，A.，＆Barfield，M.（2010）。，Application of the DBS methodology to a toxicokinetic study in rats and transferability of analysis between bioanalytical laboratories., Bioanalysis, 2(8), 1489-1499. doi:10.4155/bio.10.88 [doi]
    Silva AV, Norinder U, Liiv E, Platzack B, Öberg M, Törnqvist E.,Associations between clinical signs and pathological findings in toxicity testing，Altex。2020年10月26日DOI：10.14573 / Altex.2003311。在线之前在线。
    Zuurbier，C. J.，Heinen，A.，Koeman，A.，Stuifbergen，R.，Hakvoort，T.B.，Weber，N.C.，＆Hollmann，M. W.（2014）。，心脏保护疗效均危重取决于药理剂量，缺血持续时间，动物的健康状况以及麻醉方案的选择：叶酸的案例研究。, Journal of Translational Medicine, 12, 325-014-0325-8. doi:10.1186/s12967-014-0325-8 [doi]
    Hall, A. P., Davies, W., Stamp, K., Clamp, I., & Bigley, A. (2013),Comparison of computerized image analysis with traditional semiquantitative scoring of perls' prussian blue stained hepatic iron deposition.，毒理病理学，41（7），992-1000。DOI：10.1177 / 0192623313476576 [DOI]
    Roques, B. B., Lacroix, M. Z., Puel, S., Gayrard, V., Picard-Hagen, N., Jouanin, I., . . . Viguie, C. (2012).,CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats.，毒理学科学：毒理学学会官方杂志，127（1），29-41。DOI：10.1093 / TOXSCI / KFS094 [DOI]
    Harris, Stephen B; Hardisty, Jerry F; Hayes, A Wallace; Weber, Klaus;,Developmental and reproductive toxicity studies of BIA 10-2474, Regulatory toxicology and pharmacology : RTP Vol., 2019
    Harris SB, Hardisty JF, Hayes AW, Weber K.,Developmental and reproductive toxicity studies of BIA 10-2474，法调节毒药药物。2020 Mar;111:104543. doi: 10.1016/j.yrtph.2019.104543. Epub 2019 Nov 20.
    Panknin O，Wagenfeld A，Bone W，Bender E，Nowak-Reppel K，Fernández-MontalvánAE，Nubbemeyer R，BäurleS，戒指S，Schmees N，Proien O，SchäferM，Friedrich C，Zollner TM，Steinmeyer A，MuellerT，Langer G.，Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women, J Med Chem. 2020 Oct 22;63(20):11854-11881. doi: 10.1021/acs.jmedchem.0c01076. Epub 2020 Oct 6.
    Finlay, M. R., Anderton, M., Ashton, S., Ballard, P., Bethel, P. A., Box, M. R., . . . Wrigley, G. L. (2014).,Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor., Journal of Medicinal Chemistry, 57(20), 8249-8267. doi:10.1021/jm500973a [doi]
    Bisson，J.F.，Daubie，S.，Hidalgo，S.，Guillemet，D.，＆Linares，E。（2010）。，Diuretic and antioxidant effects of cacti-nea, a dehydrated water extract from prickly pear fruit, in rats, Phytotherapy Research : PTR, 24(4), 587-594. doi:10.1002/ptr.2996 [doi]
    Fennell，T. R.，Snyder，R.，Hansen，B.，＆Friedman，M。（2015）。，在Wistar Han大鼠丙烯酰胺的2年生物测定中丙烯酰胺和丙酰胺的剂量术。，毒理学科学：毒理学学会官方杂志，146（2），386-394。DOI：10.1093 / TOXSCI / KFV104 [DOI]
    Fennell，T. R.，Snyder，R.，Hansen，B.，＆Friedman，M。（2015）。，在Wistar Han大鼠丙烯酰胺2年生物测定中的丙烯酰胺和丙酰胺的剂量术。，毒理学科学：毒理学学会官方杂志，146（2），386-394。DOI：10.1093 / TOXSCI / KFV104 [DOI]
    Klose, M., Grote, K., Spathmann, O., Streckert, J., Clemens, M., Hansen, V. W., & Lerchl, A. (2014).,Effects of early-onset radiofrequency electromagnetic field exposure (GSM 900 MHz) on behavior and memory in rats.，放射研究，182（4），435-447。DOI：10.1667 / RR13695.1 [DOI]
    斯科特H，Tjernströmn，罗马E.，根据自愿的酒精intak对房地产的影响e in male and female Wistar rats， 酒精。2020 8月; 86：121-128。DOI：10.1016 / J.ALOCKET.2019.12.005。EPUB 2020 1月21日。
    Devonshire，I. M.，Grandy，T. H.，Dommett，E. J.，＆Greenfield，S. A.（2010），氨基甲酸酯麻醉对大鼠桶皮层中的感觉加工的影响，包括光学成像和电生理学。，欧洲神经科学杂志，32（5），786-797。DOI：10.1111 / J.1460-9568.2010.07322.x [DOI]
    Verma，R.，Kushwah，L.，Gohel，D。，Patel，M.，Marvania，T.，＆Balakrishnan，S。（2013）。，评估槲皮素对Wistar大鼠肺纤维蛋白诱导的肺纤维化的改进潜力。，肺部医学，2013,921724.Doi：10.1155 / 2013/921724 [Doi]
    Verma，R.，Brahmankar，M.，Kushwah，L.，＆Suresh，B。（2013）。，Evaluating the inhibitory potential of sulindac against the bleomycin-induced pulmonary fibrosis in wistar rats.，环境毒理学和药理学，36（3），769-778。DOI：10.1016 / J.etap.2013.07.011 [DOI]
    Tulinska, J., Adel-Patient, K., Bernard, H., Liskova, A., Kuricova, M., Ilavska, S., . . . Steinberg, P. (2018).,Wistar Han RCC大鼠中的体液和细胞免疫反应喂养两种转基因玉米MON810品种90天（欧盟第7框架计划项目恩典）。，毒理学档案，92（7），2385-2399。DOI：10.1007 / S00204-018-2230-Z [DOI]
    Masuda-herrera，Melisa J;Dobo，Krista L;肯尼昂，米歇尔o;肯尼，朱莉娅D;加洛韦，希拉米;Escobar，Patricia a;reddy，m vijayaraj;快乐，罗伯特A;Trejo-Martin，Alejandra;棕色，克伦; Mckeon, Marie; Young, Megan; Bruce, Shannon; Pant, Kamala; Dutta, Aparajita; Kulkarni, Rohan; Bercu, Joel P,体内诱变芳基硼酸和酯的诱变试验。, Environmental and molecular mutagenesis Vol.60, 2019
    Dietrich, H., & Jenck, F. (2010).,Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant.，精神医药学，212（2），145-154。DOI：10.1007 / S00213-010-1933-5 [DOI]
    Steinberg, Pablo; van der Voet, Hilko; Goedhart, Paul W; Kleter, Gijs; Kok, Esther J; Pla, Maria; Nadal, Anna; Zeljenková, Dagmar; Alá?ová, Radka; Babincová, Júlia; Rollerová, Eva; Ja?u?ová, So?a; Kebis, Anton; Szabova, Elena; Tulinská, Jana; Líšková, Aurélia; Takácsová, Melinda; Mikušová, Miroslava Lehotská; Krivošíková, Zora; Spök, Armin; Racovita, Monica; de Vriend, Huib; Alison, Roger; Alison, Clare; Baumgärtner, Wolfgang; Becker, Kathrin; Lempp, Charlotte; Schmicke, Marion; Schrenk, Dieter; Pöting, Annette; Schiemann, Joachim; Wilhelm, Ralf;,副高分子和慢性毒性/致癌性研究缺乏不良反应，抗甘藻酸盐耐血液改性玉米NK603在Wistar HAN RCC大鼠中的疾病。，毒理学档案Vol.93，2019
    Weber，K.，Germann，P.G.，Iwata，H.，Hardisty，J.，Kaufmann，W.，＆Rosenbruch，M。（2009）。，Lesions in the larynx of wistar RccHan: WIST rats, Journal of Toxicologic Pathology, 22(4), 229-246. doi:10.1293/tox.22.229 [doi]
    Pothmann, D., Simar, S., Schuler, D., Dony, E., Gaering, S., Le Net, J. L., . . . Regnier, J. F. (2015),Lung inflammation and lack of genotoxicity in the comet and micronucleus assays of industrial multiwalled carbon nanotubes graphistrength((c)) C100 after a 90-day nose-only inhalation exposure of rats., Particle and Fibre Toxicology, 12, 21-015-0096-2. doi:10.1186/s12989-015-0096-2 [doi]
    格雷戈里M，纳勒SW，弗科MC，Chamanza R，Piaia A，Hall AP。，Multisite Analysis of Lesions in the Respiratory Tract of the Rat and Nonhuman Primate (Cynomolgus Monkey) Exposed to Air, Vehicle, and Inhaled Small Molecule Compounds, Toxicol Pathol. 2020 Nov 10:192623320953839. doi: 10.1177/0192623320953839. Online ahead of print.
    Bergner, R., Siegrist, B., Gretz, N., Pohlmeyer-Esch, G., & Kranzlin, B. (2015).,Nephrotoxicity of ibandronate and zoledronate in wistar rats with normal renal function and after unilateral nephrectomy.，药理学研究：意大利药理学学会官方杂志，99,16-22。DOI：S1043-6618（15）00085-7 [PII]
    Zeljenkova，D.，Alacova，R.，Ondrejkova，J.，Ambrusova，K。，Bartusova，M.，Kebis，A。。。。Steinberg，P。（2016）。，One-year oral toxicity study on a genetically modified maize MON810 variety in wistar han RCC rats (EU 7th framework programme project GRACE)、档案of Toxicology, 90(10), 2531-2562. doi:10.1007/s00204-016-1798-4 [doi]
    Hayes AW, Hardisty JF, Harris SB, Okazaki Y, Weber K.,Oral repeated-dose toxicity studies of BIA 10-2474 in Wistar rat，法调节毒药药物。2020 Mar; 111：104540。DOI：10.1016 / J.YRTPH.2019.104540。EPUB 2019年11月20日。
    MacDowell, K. S., Caso, J. R., Martin-Hernandez, D., Madrigal, J. I., Leza, J. C., & Garcia-Bueno, B. (2014).,Paliperidone prevents brain toll-like receptor 4 pathway activation and neuroinflammation in rat models of acute and chronic restraint stress.，国际神经脑能科医生/官方科学杂志Collegium Internationale Neuropsychmacologicum（Cinp），18（3），10.1093 / IJNP / PYU070。DOI：10.1093 / IJNP / PYU070 [DOI]
    Sternebring, O., Christensen, J. K., & Bjornsdottir, I. (2016),在大鼠中PEG化RFIX（非焦饼βPEGOL，N9-GP）的药代动力学，组织分布，排泄和代谢物分析。，欧洲药学杂志：欧洲医药科学联合会官方杂志，92,163-172。DOI：10.1016 / J.EJPS.2016.06.025 [DOI]
    Tuppurainen, L., Sallinen, H., Kokki, E., Koponen, J., Anttila, M., Pulkkinen, K., . . . Yla-Herttuala, S. (2013).,患者腺病毒基因治疗与SVEGFR-2和SVEGFR-3结合化疗卵巢癌的临床前安全性，毒理学和生物分布研究，人类基因治疗。临床发育，24（1），29-37。DOI：10.1089 / HUMC.2013.006 [DOI]
    Hall, A. P., Escott, K. J., Sanganee, H., & Hickling, K. C. (2015),Preclinical toxicity of AZD7969: Effects of GSK3beta inhibition in adult stem cells，毒理学病理学，43（3），384-399。DOI：10.1177 / 0192623314544468 [DOI]
    Elmore，S. A.，Hoenerhoff，M.，Katsuta，O.，Kokoshima，H.，Maronpot，R.，Nagai，H.，。。。Yoshizawa，K。（2013）。，Proceedings of the 2013 joint JSTP/NTP satellite symposium., Journal of Toxicologic Pathology, 26(2), 231-257. doi:10.1293/tox.26.231 [doi]
    MacDowell，K.，Garcia-Bueno，B.，Madrigal，J.L.，Parellada，M.，Arango，C.，Mico，J.A。，＆Leza，J.C。（2013）。，Risperidone标准化增加的炎症参数，并在神经引发模型中恢复抗炎途径。,国际Neuropsychopharmaco杂志》上logy / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 16(1), 121-135. doi:10.1017/S1461145711001775 [doi]
    Healing, G., Sulemann, T., Cotton, P., Harris, J., Hargreaves, A., Finney, R., . . . Burdett, L. (2015).,Safety data on 19 vehicles for use in 1 month oral rodent pre-clinical studies: Administration of hydroxypropyl-ss-cyclodextrin causes renal toxicity., Journal of Applied Toxicology : JAT, doi:10.1002/jat.3155 [doi]
    Coulson, M., Mitchard, T., Bickerton, S., Harris, J., Betts, C., & Stewart, J. (2013).,用GNRH激动剂和内皮素受体拮抗剂处理雄性大鼠抑制蛋白B反应。，出生缺陷研究。Bart B，发育和生殖毒理学，98（1），82-90。DOI：10.1002 / BDRB.21044 [DOI]
    Annas, A., Berg, A. L., Nyman, E., Meijer, T., Lundgren, V., Franzen, B., & Stahle, L. (2015).,Towards development of a dermal pain model: In vitro activation of rat and human transient receptor potential ankyrin repeat 1 and safe dermal injection of o-chlorobenzylidene malononitrile to rat, Basic & Clinical Pharmacology & Toxicology, 117(6), 375-382. doi:10.1111/bcpt.12427 [doi]
    黑士，J.，Anyangwe，N.，Tran，N.，Edwards，J.，Beilstein，P.，＆Lopez，J.（2015）。，Toxicological evaluation of an olive extract, H35: Subchronic toxicity in the rat., Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 84, 18-28. doi:S0278-6915(15)30015-6 [pii]
    AUNON-CALLES，D.，CANUT，L.，＆Visioli，F。（2013）。，纯羟基吡咯醇的毒理学评价, Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 55, 498-504. doi:10.1016/j.fct.2013.01.030 [doi]
    Dodd，D.，Willson，G.，Parkinson，H.，＆Bermudez，E。（2013），Two-year drinking water carcinogenicity study of methyl tertiary-butyl ether (MTBE) in wistar rats., Journal of Applied Toxicology : JAT, 33(7), 593-606. doi:10.1002/jat.1776 [doi]