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    Gene therapy

    Vandergaast, Rianna; Khongwichit, Sarawut; Jiang, Huailei; DeGrado, Timothy R; Peng, Kah-Whye; Smith, Duncan R; Russell, Stephen J; Suksanpaisan, Lukkana,Enhanced noninvasive imaging of oncology models using the NIS reporter gene and bioluminescence imaging., Cancer gene therapy Vol.14, 2019

    General studies

    Taglialegna, Agustina; Varela, Maria C; Rosato, Roberto R; Rosato, Adriana E;,VraSR and Virulence Trait Modulation during Daptomycin Resistance in Methicillin-Resistant Staphylococcus aureus Infection, mSphere Vol.4, 2019

    免疫学

    刘,B.,Kong,L.,Han,K.,Hong,H.,Marcus,W. D.,Chen,X.,。。。Wong,H. C.(2016)。,A novel fusion of ALT-803 (interleukin (IL)-15 superagonist) with an antibody demonstrates antigen-specific antitumor responses, The Journal of Biological Chemistry, 291(46), 23869-23881. doi:M116
    Izhak, L., Wildbaum, G., Zohar, Y., Anunu, R., Klapper, L., Elkeles, A., . . . Karin, N. (2009).,一种新的重组融合蛋白,编码CCR2的第三细胞外(E3)结构域的20-氨基酸残基中和CCl2的生物活性。, Journal of Immunology (Baltimore, Md.: 1950), 183(1), 732-739. doi:10.4049/jimmunol.0802746 [doi]
    Stangl,S.,Wortmann,A.,Guertler,U.,&Multhoff,G.(2006),用人IL-2 / TKD活化的NK细胞控制SCID /米色小鼠中血糖癌的控制。。免疫学(巴尔的摩,MD杂志:1950),176(10),6270-6276。DOI:176/10/6270 [PII]
    Porkka,K.,Koskenmsa,P.,Lundan,T.,Rimpilainen,J.,Mustjoki,S.,Smykla,R.,。。。Lee,F. Y.(2008),Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system philadelphia chromosome-positive leukemia., Blood, 112(4), 1005-1012. doi:10.1182/blood-2008-02-140665 [doi]
    Brown, M. E., Rondon, E., Rajesh, D., Mack, A., Lewis, R., Feng, X., . . . Nuwaysir, E. F. (2010).,Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes. PloS,plos一个,5(6),E11373。DOI:10.1371 / journal.pone.0011373 [DOI]
    Gavrilov,S。,玛尔特,D.,Douglas,N.C.,Prosser,R.W.,Khalid,I.,Sauer,M.V.,。。。Papaioannou,V. E.(2011),Derivation of two new human embryonic stem cell lines from nonviable human embryos.,干细胞国际,2011,765378.Doi:10.4061 / 2011/765378 [DOI]
    Yipp, B. G., Hickey, M. J., Andonegui, G., Murray, A. G., Looareesuwan, S., Kubes, P., & Ho, M. (2007).,CD36,ICAM-1和P-SELETIN在体内疟原虫细胞曲线中的差异作用。, Microcirculation (New York, N.Y.: 1994), 14(6), 593-602. doi:781394714 [pii]
    Mueller,K.,Schweier,O.,&Pircher,H.(2008)。,IL-2-与IL-15刺激的CD8 T细胞在采用免疫疗法中的疗效,欧洲免疫学杂志,38(10),2874-2885。DOI:10.1002 / eji.200838426 [DOI]
    Domev, H., Amit, M., Laevsky, I., Dar, A., & Itskovitz-Eldor, J. (2012),Efficient engineering of vascularized ectopic bone from human embryonic stem cell-derived mesenchymal stem cells.,组织工程。第一个,18(21-22),2290-2302。DOI:10.1089 / ten.tea.2011.0371 [DOI]
    Yu,J.,Chau,K.F.,Vodyanik,M. A.,Jiang,J.,&Jiang,Y。(2011)。,无高的饲养饲养的重新编程用小分子重新编程, PloS One, 6(3), e17557. doi:10.1371/journal.pone.0017557 [doi]
    Mack, A. A., Kroboth, S., Rajesh, D., & Wang, W. B. (2011).,Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors.,plos一个,6(11),E27956。DOI:10.1371 / journal.pone.0027956 [DOI]
    Kalac, M., Scotto, L., Marchi, E., Amengual, J., Seshan, V. E., Bhagat, G., . . . O'Connor, O. A. (2011).,HDAC抑制剂和Defitabine是高度协同的,与DLBCL模型中的独特基因表达和表观遗传谱相关。, Blood, 118(20), 5506-5516. doi:10.1182/blood-2011-02-336891 [doi]
    Brignole, C., Pastorino, F., Marimpietri, D., Pagnan, G., Pistorio, A., Allen, T. M., . . . Ponzoni, M. (2004).,免疫细胞介导的GD2靶向脂质体C-MYB反义寡核苷酸的抗肿瘤活性含CPG基序。, Journal of the National Cancer Institute, 96(15), 1171-1180. doi:10.1093/jnci/djh221 [doi]
    金,Ik Sun;高,杨;威尔特,托马斯;王,海;刘军;janghorban,mahnaz;盛,柯威;牛,伊希;Goldstein,Amit;赵,na; Bado, Igor; Lo, Hin-Ching; Toneff, Michael J; Nguyen, Tuan; Bu, Wen; Jiang, Weiyu; Arnold, James; Gu, Franklin; He, Jian; Jebakumar, Deborah; Walker, Kimberly; Li, Yi; Mo, Qianxing; Westbrook, Thomas F; Zong, Chenghang; Rao, Arundhati; Sreekumar, Arun; Rosen, Jeffrey M; Zhang, Xiang H-F;,免疫甲型乳腺癌揭示了明显的骨髓细胞谱和免疫疗法抗性机制。, Nature cell biology Vol.21, 2019
    Lum, H. D., Buhtoiarov, I. N., Schmidt, B. E., Berke, G., Paulnock, D. M., Sondel, P. M., & Rakhmilevich, A. L. (2006,体内CD40结扎可以诱导涉及巨噬细胞的T细胞无关的抗肿瘤效果。, Journal of Leukocyte Biology, 79(6), 1181-1192. doi:jlb.0405191 [pii]
    Keren, Aviad; Gilhar, Amos; Ullmann, Yehuda; Zlotkin-Fruši?, Marina; Soroka, Yoram; Domb, Abraham J; Levite, Mia;,Instantaneous depolarization of T cells via dopamine receptors, and inhibition of activated T cells of Psoriasis patients and inflamed human skin, by D1-like receptor agonist,免疫学Vol.158,2019
    Bruin, J. E., Rezania, A., Xu, J., Narayan, K., Fox, J. K., O'Neil, J. J., & Kieffer, T. J. (2013).,人类胚胎干细胞的成熟和功能ll-derived pancreatic progenitors in macroencapsulation devices following transplant into mice., Diabetologia, 56(9), 1987-1998. doi:10.1007/s00125-013-2955-4 [doi]
    Timaner, Michael; Kotsofruk, Ruslana; Raviv, Ziv; Magidey, Ksenia; Shechter, Dvir; Kan, Tal; Nevelsky, Alexander; Daniel, Shahar; de Vries, Elisabeth G E; Zhang, Tongwu; Kaidar-Person, Orit; Kerbel, Robert S; Shaked, Yuval;,Microparticles from tumors exposed to radiation promote immune evasion in part by PD-L1., Oncogene Vol.39, 2020
    Felder M, Kapur A, Rakhmilevich AL, Qu X, Sondel PM, Gillies SD, Connor J, Patankar MS.,Muc16抑制人和鼠先天免疫反应, Gynecol Oncol. 2019 Mar;152(3):618-628.
    Di Gialleonardo, V., Signore, A., Glaudemans, A. W., Dierckx, R. A., & De Vries, E. F. (2012).,N-(4-18F-氟苯甲酰基)白细胞介素-2,用于人活化T淋巴细胞的PET。, Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 53(5), 679-686. doi:10.2967/jnumed.111.091306 [doi]
    Suttmann,H.,Riemensberger,J.,Bentien,G.,Schmaltz,D。,罗赛斯,M.,Jocham,D.,。。。Brandau,S。(2006)。,Neutrophil granulocytes are required for effective bacillus calmette-guerin immunotherapy of bladder cancer and orchestrate local immune responses., Cancer Research, 66(16), 8250-8257. doi:66/16/8250 [pii]
    Fajardo, C. A., Guedan, S., Rojas, L. A., Moreno, R., Arias-Badia, M., de Sostoa, J., . . . Alemany, R. (2017).,Oncolytic adenoviral delivery of an EGFR-targeting T-cell engager improves antitumor efficacy, Cancer Research, 77(8), 2052-2063. doi:10.1158/0008-5472.CAN-16-1708 [doi]
    Revazova, E. S., Turovets, N. A., Kochetkova, O. D., Kindarova, L. B., Kuzmichev, L. N., Janus, J. D., & Pryzhkova, M. V. (2007).,Patient-specific stem cell lines derived from human parthenogenetic blastocysts., Cloning and Stem Cells, 9(3), 432-449. doi:10.1089/clo.2007.0033 [doi]
    Holland, M., Castro, F. V., Alexander, S., Smith, D., Liu, J., Walker, M., . . . Saha, V. (2011),RAC2,AEP和ICAM1表达与B类儿童急性淋巴细胞白血病小鼠模型中的CNS病相关, Blood, 118(3), 638-649. doi:10.1182/blood-2010-09-307330 [doi]
    Balza, E., Mortara, L., Sassi, F., Monteghirfo, S., Carnemolla, B., Castellani, P., . . . Borsi, L. (2006).,针对肿瘤坏死因子-α-肿瘤血管的靶向递送诱导治疗性T细胞介导的免疫应答,其保护宿主免受不同组织源的同源瘤,临床癌症研究:官方癌症研究官方杂志,12(8),2575-2582。DOI:12/8/2575 [PII]
    Straetemans, T., Coccoris, M., Berrevoets, C., Treffers-Westerlaken, E., Scholten, C. E., Schipper, D., . . . Debets, R. (2012).,T细胞受体基因治疗人黑色素瘤免疫缺陷小鼠:人类但不是小鼠T细胞重新培养临床研究的结果人类基因治疗,23(2),187 - 201。doi: 10.1089 /hum.2010.126 [doi]
    Elsner, L., Muppala, V., Gehrmann, M., Lozano, J., Malzahn, D., Bickeboller, H., . . . Dressel, R. (2007).,热休克蛋白HSP70促进针对表达诱导NKG2D配体的肿瘤的小鼠NK细胞活性, Journal of Immunology (Baltimore, Md.: 1950), 179(8), 5523-5533. doi:179/8/5523 [pii]
    Wu, Q. L., Buhtoiarov, I. N., Sondel, P. M., Rakhmilevich, A. L., & Ranheim, E. A. (2009).,Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia.,免疫学杂志(巴尔的摩,MD.:1950),182(11),6771-6778。DOI:10.4049 / JIMMUNOL.0801847 [DOI]

    Oncology

    勒村,瓦迪姆;马丁斯,安娜;Puhka,Maija;伊索拉,Jorma;Salmikangas,Marko;Laakkonen,Pirjo;乔富,海基;马克,马克;,一种新的抗HER2抗体 - 药物缀合物XMT-1522,用于HER2阳性乳腺和耐血液癌的胃癌。, Molecular cancer therapeutics Vol.18, 2019
    Czardybon, W., Windak, R., Golas, A., Galezowski, M., Sabiniarz, A., Dolata, I., . . . Brzozka, K. (2018),A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia., Oncotarget, 9(24), 16917-16931. doi:10.18632/oncotarget.24747 [doi]
    Landolina N, Zaffran I, Smiljkovic D, Serrano-Candelas E, Schmiedel D, Friedman S, Arock M, Hartmann K, Pikarsky E, Mandelboim O, Martin M, Valent P, Levi-Schaffer F.,Activation of Siglec-7 results in inhibition of in vitro and in vivo growth of human mast cell leukemia cells, Pharmacol Res. 2020 Aug;158:104682. doi: 10.1016/j.phrs.2020.104682. Epub 2020 Feb 5.
    Kelly, R. K., Olson, D. L., Sun, Y., Wen, D., Wortham, K. A., Antognetti, G., . . . Sanicola, M. (2011),抗体 - 细胞毒性缀合物BiiB015是克利普酰阳性肿瘤的新靶向治疗。。European Journal of Cancer (Oxford, England : 1990), 47(11), 1736-1746. doi:10.1016/j.ejca.2011.02.023 [doi]
    Urbinati,G.,Ali,H. M.,Rousseau,Q.,Chapuis,H.,Desmaele,D.,Couvreur,P.,&Massaad-Massade,L.(2015)。,Antineoplastic effects of siRNA against TMPRSS2-ERG junction oncogene in prostate cancer., PloS One, 10(5), e0125277. doi:10.1371/journal.pone.0125277 [doi]
    Adepoju, L. J., & Geiger, J. D. (2010). .,Antitumor activity of polyuridylic acid in human soft tissue and bone sarcomas., The Journal of Surgical Research, 164(1), e107-14. doi:10.1016/j.jss.2010.05.038 [doi]
    Egberts, J. H., Cloosters, V., Noack, A., Schniewind, B., Thon, L., Klose, S., . . . Trauzold, A.,Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis.,癌症研究,68(5),1443-1450。DOI:10.1158 / 0008-5472.CAN-07-5704 [DOI]
    赵,宁;孔雀,斯蒂芬妮o;罗,陈浩;海德曼,莱恩米;米饭,梅根A;Fahrenholtz,Cale D;格林,安米;Magani,Fiorella;,Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer., Science translational medicine Vol.11, 2019
    Parhi L, Alon-Maimon T, Sol A, Nejman D, Shhadeh A, Fainsod-Levi T, Yajuk O, Isaacson B, Abed J, Maalouf N, Nissan A, Sandbank J, Yehuda-Shnaidman E, Ponath F, Vogel J, Mandelboim O, Granot Z, Straussman R, Bachrach G.,Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression, Nat Commun. 2020 Jun 26;11(1):3259. doi: 10.1038/s41467-020-16967-2.
    von Karstedt, S., Conti, A., Nobis, M., Montinaro, A., Hartwig, T., Lemke, J., . . . Walczak, H. (2015).,Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis., Cancer Cell, 27(4), 561-573. doi:10.1016/j.ccell.2015.02.014 [doi]
    Pesakhov,S.,Nachliely,M.,Barvish,Z.,AQAQE,N.,Schwartzman,B.,Voronov,E.,。。。Danilenko,M。(2016),癌症选择性细胞毒性Ca2 +过载在急性髓性白血病细胞中,通过协同作用多酚姜黄素和芋糖酸进行小鼠疾病进展的衰减, Oncotarget, 7(22), 31847-31861. doi:10.18632/oncotarget.7240 [doi]
    Assimon VA, Tang Y, Vargas JD, Lee GJ, Wu ZY, Lou K, Yao B, Menon MK, Pios A, Perez KC, Madriaga A, Buchowiecki PK, Rolfe M, Shawver L, Jiao X, Le Moigne R, Zhou HJ, Anderson DJ,CB-6644是Ruvbl1 / 2复合物的选择性抑制剂,其具有抗癌活性。, ACS Chem Biol. 2019 Feb 15;14(2):236-244.
    Rakhmilevich, A. L., Buhtoiarov, I. N., Malkovsky, M., & Sondel, P. M. (2008).,CD40 ligation in vivo can induce T cell independent antitumor effects even against immunogenic tumors.,癌症免疫学,免疫疗法:CII,57(8),1151-1160。DOI:10.1007 / s00262-007-0447-4 [DOI]
    Sobot, D., Mura, S., Rouquette, M., Vukosavljevic, B., Cayre, F., Buchy, E., . . . Couvreur, P. (2017).,循环脂蛋白:一个特洛伊木马引导角鲨烯酰化药物到LDL积累的癌细胞。,分子疗法:美国基因治疗学会,25(7),1596-1605。DOI:S1525-0016(17)30234-4 [PII]
    Kaeopookum,Piriya;Petrik,米洛斯;夏天,多米尼克;Klinger,Maximilian;翟楼;Rangger,Christine;Haubner,罗兰;Haas,Hubertus;Hajduch,Marian;克里蒙罗索;Comparison of 68Ga-labeled RGD mono- and multimers based on a clickable siderophore-based scaffold.,核医学和生物学Vol.78-79,
    Stangl, S., Wortmann, A., Guertler, U., & Multhoff, G. (2006).,用人IL-2 / TKD活化的NK细胞控制SCID /米色小鼠中血糖癌的控制。,免疫学杂志(巴尔的摩,MD.:1950),176(10),6270-6276。DOI:176/10/6270 [PII]
    Glaser, G., Weroha, S. J., Becker, M. A., Hou, X., Enderica-Gonzalez, S., Harrington, S. C., & Haluska, P. (2015).,Conventional chemotherapy and oncogenic pathway targeting in ovarian carcinosarcoma using a patient-derived tumorgraft., PloS One, 10(5), e0126867. doi:10.1371/journal.pone.0126867 [doi]
    Bartalucci, N., Tozzi, L., Bogani, C., Martinelli, S., Rotunno, G., Villeval, J. L., & Vannucchi, A. M. (2013).,共靶向PI3K / MTOR和JAK2信号传导途径对肌酚瘤的肿瘤产生协同活性。, Journal of Cellular and Molecular Medicine, 17(11), 1385-1396. doi:10.1111/jcmm.12162 [doi]
    EGBERTS,J. H.,Schniewind,B.,Patzold,M.,Ketler,B.,Tepel,J.,Kalthoff,H.,&Trauzold,A.(2008)。,Dexamethasone reduces tumor recurrence and metastasis after pancreatic tumor resection in SCID mice.,癌症生物学和治疗,7(7),1044-1050。DOI:6099 [PII]
    Nachliely M, Trachtenberg A, Khalfin B, Nalbandyan K, Cohen-Lahav M, Yasuda K, Sakaki T, Kutner A, Danilenko M.,Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model.。J类固醇生物切基Mol Biol。2019年4月; 188:8-16
    Hiriyan,J.,Shivarudraiah,P.,Gavara,G.,Annamalai,P.,Natensan,S.,Sambasivam,G.,&Sukumaran,S. K.(2015)。,Discovery of PAT-1102, a novel, potent and orally active histone deacetylase inhibitor with antitumor activity in cancer mouse models, Anticancer Research, 35(1), 229-237. doi:35/1/229 [pii]
    Fonti, Claire; Saumet, Anne; Abi-Khalil, Amanda; Orsetti, Béatrice; Cleroux, Elouan; Bender, Ambre; Dumas, Michael; Schmitt, Emeline; Colinge, Jacques; Jacot, William; Weber, Michael; Sardet, Claude; du Manoir, Stanislas; Theillet, Charles;,Distinct oncogenes drive different genome and epigenome alterations in human mammary epithelial cells, International journal of cancer Vol.145, 2019
    钥匙,J.,Aryal,S.,Gentile,F.,Ananta,J.S.,Zhong,M.,Landis,M. D.和Decuzzi,P.(2013)。,Engineering discoidal polymeric nanoconstructs with enhanced magneto-optical properties for tumor imaging,生物材料,34(21),5402-5410。DOI:10.1016 / J.Biomaterials.2013.03.078 [DOI]
    Natoni, A., Smith, T. A. G., Keane, N., McEllistrim, C., Connolly, C., Jha, A., . . . O'Dwyer, M. E. (2017).,E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271., Leukemia, 31(12), 2642-2651. doi:10.1038/leu.2017.123 [doi]
    ven de Vijver K,Van der Meulen J,Taminau J,Wagemans G,Venys H,Van Dorpe J,Berx G,Ceelen W,Van Bocxlaer J,De Wever O.,细胞系的建立和特征and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma, Sci Rep. 2020 Apr 21;10(1):6688. doi: 10.1038/s41598-020-63738-6.
    Naumann, C. M., Sperveslage, J., Hamann, M. F., Leuschner, I., Weder, L., Al-Najar, A. A., . . . Kalthoff, H. (2012).,Establishment and characterization of primary cell lines of squamous cell carcinoma of the penis and its metastasis., The Journal of Urology, 187(6), 2236-2242. doi:10.1016/j.juro.2012.01.035 [doi]
    Srivastava, Swati; Nataraj, Nishanth Belugali; Sekar, Arunachalam; Ghosh, Soma; Bornstein, Chamutal; Drago-Garcia, Diana; Roth, Lee; Romaniello, Donatella; Marrocco, Ilaria; David, Eyal; Gilad, Yuval; Lauriola, Mattia; Rotkopf, Ron; Kimchi, Adi; Haga, Yuya; Tsutsumi, Yasuo; Mirabeau, Olivier; Surdez, Didier; Zinovyev, Andrei; Delattre, Olivier; Kovar, Heinrich; Amit, Ido; Yarden, Yosef;,ETS蛋白质与糖皮质激素受体结合:与育种肉瘤治疗的相关性,Cell Reports Vol.29,2019
    Owonikoko, Taofeek K; Zhang, Guojing; Lallani, Shenila B; Chen, Zhengjia; Martinson, Deborah E; Khuri, Fadlo R; Lonial, Sagar; Marcus, Adam; Sun, Shi-Yong;,亚硫夫司和Pasireotide在甲状腺癌细胞系和异种移植模型中的临床前疗效评价。, PloS one Vol.14, 2019
    Bailey,K.M.,Cornnell,H. H. H.,Ibrahim-Hashim,A.,Wojtkowiak,J.W.,Hart,C. P.,张,X.,Zhang,X.,。。。吉利斯,R. J.(2014)。,Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer., PloS One, 9(12), e113586. doi:10.1371/journal.pone.0113586 [doi]
    Cody,J.,Rivera,A. A.,Lyons,G. R.,Yang,S. W.,Wang,M.,Ashley,J.W.,。。。道格拉斯,J.T.(2013)。,从复制腺病毒中的骨蛋白酶的表达抑制了小鼠模型中前列腺癌骨转移的进展。, Laboratory Investigation; a Journal of Technical Methods and Pathology, 93(3), 268-278. doi:10.1038/labinvest.2012.179 [doi]
    Ronca R, Ghedini GC, Maccarinelli F, Sacco A, Locatelli SL, Foglio E, Taranto S, Grillo E, Matarazzo S, Castelli R, Paganini G, Desantis V, Cattane N, Cattaneo A, Mor M, Carlo-Stella C, Belotti A, Roccaro AM, Presta M, Giacomini A.,FGF捕获通过抑制多发性骨髓瘤增长ugh c-Myc Degradation-Induced Mitochondrial Oxidative Stress, Cancer Res. 2020 Jun 1;80(11):2340-2354. doi: 10.1158/0008-5472.CAN-19-2714. Epub 2020 Feb 24.
    Kurdow, R., Boehle, A. S., Haye, S., Boenicke, L., Schniewind, B., Dohrmann, P., & Kalthoff, H. (2002).,Ganciclovir prodrug therapy is effective in a murine xenotransplant model of human lung cancer, The Annals of Thoracic Surgery, 73(3), 905-910.
    von Forstner, C., Egberts, J. H., Ammerpohl, O., Niedzielska, D., Buchert, R., Mikecz, P., . . . Brenner, W. (2008).,基因表达模式和18F-FDG,18F-FLT和18F-FEC在胰腺癌的原位小鼠异种持续模型的PET / MRI中吸收18F-FEC。, Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 49(8), 1362-1370. doi:10.2967/jnumed.107.050021 [doi]
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