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    Cellular therapies

    Brott, David A; Katein, Anne; Thomas, Heath; Lawton, Michael; Montgomery, Robert R; Richardson, Rudy J; Louden, Calvert S;,von Willebrand因子和von Willebrand因子肽在血管内皮细胞活化，扰动和/或损伤模型中的吞噬。, Toxicologic pathology Vol.42, 2014
    Applefeld WN, Wang J, Sun J, Pockros BM, Solomon SB, Feng J, Risoleo T, Cortés-Puch I, Gouél-Cheron A, Klein HG, Natanson C.,In canine bacterial pneumonia circulating granulocyte counts determine outcome from donor cells, Transfusion. 2020 Apr;60(4):698-712. doi: 10.1111/trf.15727. Epub 2020 Feb 22.
    Doi, Takuya; Tomonari, Yuki; Kawasako, Kazufumi; Yamada, Naoaki; Tsuchitani, Minoru;,Lymphocytic adrenal medullitis and lymphocytic thyroiditis in a laboratory beagle dog., The Journal of veterinary medical science Vol.79, 2017
    vrecenak，杰西D;Pearson，Erik G;Todorow，Carlyn A;李，海英;约翰逊，标记P;片状，艾伦W;Preclinical Canine Model of Graft-versus-Host Disease after In Utero Hematopoietic Cell Transplantation., Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Vol.24, 2018
    vrecenak，杰西D;Pearson，Erik G;桑德，马修T;Todorow，Carlyn A;李，海英;adru，Antoneta;布塔蒂，三等教育;佩兰托，威廉H;约翰逊，标记P;片状，艾伦W;Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation., Blood Vol.124, 2014
    麦吉尔，乔迪L;nair，arathy d s;程，川敏;rusk，rachel a;Jaworski，Deborah C;甘塔，罗马r;，Vaccination with an Attenuated Mutant of Ehrlichia chaffeensis Induces Pathogen-Specific CD4+ T Cell Immunity and Protection from Tick-Transmitted Wild-Type Challenge in the Canine Host, PloS one Vol.11, 2016

    General studies

    Rossman EI, Cools F, Cordes J, Dhuyvetter D, Doyle JM, Friedrichs GS, Guth B, Neradilek MB, Parish ST, Pierson JB, Polissar N, Tang HM.,Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation, J Pharmacol Toxicol Methods. 2020 Sep;105:106897. doi: 10.1016/j.vascn.2020.106897. Epub 2020 Jul 12.
    olías-molero艾，莫伦多，普罗兰MJ，Jiménez-antónMD，Day Mj，Domínguezm，Alunda JM。，Infection of dogs by Leishmania infantum elicits a general response of IgG subclasses, Sci Rep. 2020 Nov 2;10(1):18826. doi: 10.1038/s41598-020-75569-6.
    Uchida, Mitsuhiro; Ito, Fumi; Tsuchiya, Toshiyuki; Shoji, Yoko; Kurosawa, Toru;,小猎犬犬的新型表型，其特征在于皮肤反应对皮肤肥大细胞脱粒的化合物48/80。，实验动物Vol.64,2015

    Ocular studies

    Durairaj, Chandrasekar; Shen, Jie; Cherukury, Madhu;,基于基于的平移药代动力学 - 药效模型预测青光眼或眼高血压患者药物的眼压降低效果。, Pharmaceutical research Vol.31, 2014
    李，苏珊;布克，詹姆斯;沉，杰;Almazan，Alexandra;奥里拉，Werhner;哈尔斯，帕特里克;张，简;李华江;struble，克雷格;米勒，保罗e; Robinson, Michael R,Bimatoprost sustained-release intracameral implant reduces episcleral venous pressure in dogs.，兽医眼科Vol.21，2018
    Gronkiewicz, K M; Giuliano, E A; Kuroki, K; Bunyak, F; Sharma, A; Teixeira, L B C; Hamm, C W; Mohan, R R;,Development of a novel in vivo corneal fibrosis model in the dog., Experimental eye research Vol.143, 2016
    Gronkiewicz, Kristina M; Giuliano, Elizabeth A; Sharma, Ajay; Mohan, Rajiv R;,Effects of topical hyaluronic acid on corneal wound healing in dogs: a pilot study.，兽医眼科vol.20，2017年
    Mowat, Freya M; Wise, Elisabeth; Oh, Annie; Foster, Melanie L,In vivo electroretinographic differentiation of rod, short-wavelength and long/medium-wavelength cone responses in dogs using silent substitution stimuli., Experimental eye research Vol.185, 2019
    密封，詹妮弗r;罗宾逊，迈克尔罗;布克，詹姆斯;Bejanian，码头;Coote，Michael;Attar，Mayssa;，Intracameral Sustained-Release Bimatoprost Implant Delivers Bimatoprost to Target Tissues with Reduced Drug Exposure to Off-Target Tissues., Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Vol.35,
    Chung, Jou-Ku; Spencer, Elizabeth; Hunt, Matthew; McCauley, Thomas;,Ocular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs., the official journal of the Association for Ocular Pharmacology and Therapeutics Vol.34,
    Mowat, F M; Gornik, K R; Dinculescu, A; Boye, S L; Hauswirth, W W; Petersen-Jones, S M; Bartoe, J T;,Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach., Gene therapy Vol.21, 2014

    Pharmacology

    Vick, Andrew; Wolff, Ronald; Koester, Alan; Reams, Rachel; Deaver, Daniel R; Heidel, Shawn,6个月的吸入研究表征人胰岛素吸入粉（HIIP）的毒性，药代动力学和药效学术语。, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine Vol.20, 2007
    Kendrick J, Stow R, Ibbotson N, Adjin-Tettey G, Murphy B, Bailey G, Miller J, Helleberg H, Finderup Grove M, Øvlisen K, Hansen JJ.,A novel welfare and scientific approach to conducting dog metabolism studies allowing dogs to be pair housed, Lab Anim. 2020 Dec;54(6):588-598. doi: 10.1177/0023677220905330. Epub 2020 Feb 16.
    Marier, J F; Beaudry, F; Ducharme, M P; Fortin, D; Moreau, J P; Massé, R; Vachon, P;,A pharmacokinetic study of amoxycillin in febrile beagle dogs following repeated administrations of endotoxin., Journal of veterinary pharmacology and therapeutics Vol.24, 2001
    Ling, Xiang; Wu, Wenjie; Fan, Chuandong; Xu, Chao; Liao, Jianqun; Rich, Laurie J; Huang, Ruea-Yea; Repasky, Elizabeth A; Wang, Xinjiang; Li, Fengzhi,An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer., Journal of experimental & clinical cancer research : CR Vol.37, 2018
    Budachetri K, Teymournejad O, Lin M, Yan Q, Mestres-Villanueva M, Brock GN, Rikihisa Y.,An Entry-Triggering Protein of Ehrlichia Is a New Vaccine Candidate against Tick-Borne Human Monocytic Ehrlichiosis, mBio. 2020 Jul 28;11(4):e00895-20. doi: 10.1128/mBio.00895-20.
    Baird, Theodore J; Aulbach, Adam; ODonohue, Kyle P; Yoder, Joshua D; Dalton, Jill A; Gauvin, David V;,后退ground variability in standard clinical pathology biomarkers in beagle dogs instrumented with chronic indwelling telemetry devices., Journal of pharmacological and toxicological methods Vol.69,
    Ooms, Tara G; Way, Holly L; Bley, John A;,Clinical and hematological effects of serial phlebotomy performed on laboratory beagles., Contemporary topics in laboratory animal science Vol.43, 2004
    Roberts A, Grafton G, Powell AD, Brock K, Chen C, Xie D, Huang J, Liu S, Cooper AJ, Brady CA, Qureshi O, Stamataki Z, Manning DD, Moore NA, Sargent BJ, Guzzo PR, Barnes NM.,CSTI-300（SMP-100）;一种新的5-HT（3）受体部分激动剂，潜力可治疗肠综合征或癌综合征的肠综合征患者, J Pharmacol Exp Ther. 2020 Apr;373(1):122-134. doi: 10.1124/jpet.119.261008. Epub 2020 Feb 26.
    Mitchell, Sheila M; Zajac, Anne M; Charles, Sam; Duncan, Robert B; Lindsay, David S;,Cystoisospora canis Nemeséri, 1959 (syn. Isospora canis), infections in dogs: clinical signs, pathogenesis, and reproducible clinical disease in beagle dogs fed oocysts.，寄生虫学杂志Vol.93，2007
    Wilson, James P; Cobb, Ronald R; Dungan, Nathanael W; Matthews, Laura L; Eppler, Bärbel; Aiello, Kenneth V; Curtis, Shiro; Boger, Teannetta; Guilmette, Raymond A; Weber, Waylon; Doyle-Eisele, Melanie; Talton, James D;,通过在比猎犬犬的新型口服施用的二亚乙基三胺丙二酸酯（DTPA）配方来装饰系统分布的亚美。, Health physics Vol.108, 2015
    Dhollander, Aad; Malone, Amanda; Price, James; Getgood, Alan;,比格犬膝关节软骨体积和表面积的测定, a pilot study. Journal of experimental orthopaedics Vol.4, 2017
    Shen J, Moats RA, Pollack HA, Robinson MR, Attar M.,Distribution of (14)C-Latanoprost Following a Single Intracameral Administration Versus Repeated Topical Administration, Ophthalmol Ther. 2020 Dec;9(4):929-940. doi: 10.1007/s40123-020-00285-3. Epub 2020 Aug 1.
    Houle, Christopher D; Finch, Gregory L; Mauthe, Robert J; Potter, David M; Walisser, Jacqueline A; Gardner, Iain B; DeWit, Robert H;,Effects of lersivirine on canine and rodent thyroid function., Toxicologic pathology Vol.42, 2014
    Borron, Stephen W; Stonerook, Michael; Reid, Frances,Efficacy of hydroxocobalamin for the treatment of acute cyanide poisoning in adult beagle dogs., Clinical toxicology (Philadelphia, Pa.) Vol.44 Suppl 1, 2006
    克雷梅勒，约翰j;票据，安德鲁j;汉塔纳尔·汉克;陈，肝;梅尔，威廉A;osinski，标志a;Foley，C迈克尔;，Evaluation of cardiovascular changes in dogs administered three positive controls using jacketed external telemetry-blood pressure (JET-BP).，药理毒理学方法杂志Vol.75，
    Richards D，Bamford M，Liefaard L，Haque N，Lewis G，Storey J，Fernando D，Kumar S，Thompson D，Holmes DS。，Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap, Br J Pharmacol. 2020 Apr;177(8):1853-1864. doi: 10.1111/bph.14956. Epub 2020 Feb 11.
    Lee, David S H; Pai, Y; Chang, Steve; Kim, D H;,Microstructure, physical properties, and bone regeneration effect of the nano-sized ?--tricalcium phosphate granules., Materials science & engineering. C, Materials for biological applications Vol.58, 2016
    Highland, Jaclyn N; Morris, Patrick J; Zanos, Panos; Lovett, Jacqueline; Ghosh, Soumita; Wang, Amy Q; Zarate, Carlos A; Thomas, Craig J; Moaddel, Ruin; Gould, Todd D;,Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ( 2R,6R)-hydroxynorketamine., Journal of psychopharmacology (Oxford, England) Vol.75, 2018
    Shin HW, Kim JE, Park YJ.,Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs, Pharmaceutics. 2021 Jan 6;13(1):E63. doi: 10.3390/pharmaceutics13010063.
    Shen J, Robinson MR, Struble C, Attar M.,Nonclinical Pharmacokinetic and Pharmacodynamic Assessment of Bimatoprost Following a Single Intracameral Injection of Sustained-Release Implants，译音。2020 3月20日; 9（4）：20。DOI：10.1167 / TVST.9.4.20。黯然聚映2020 3月
    Mudie DM, Stewart AM, Biswas N, Brodeur TJ, Shepard KB, Smith A, Morgen MM, Baumann JM, Vodak DT.,Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole; In Vivo and In Vitro Assessment，mol pharm。2020年12月7日; 17（12）：4463-4472。DOI：10.1021 / ACS.MOLPRAMASEUT.0C00471。EPUB 2020 SEP 4。
    Cekanova M, Pandey S, Olin S, Ryan P, Stokes JE, Hecht S, Martin-Jimenez T, Uddin MJ, Marnett LJ.,Pharmacokinetic characterization of fluorocoxib D, a cyclooxygenase-2-targeted optical imaging agent for detection of cancer，j生物选择。2020 8月; 25（8）：086005。DOI：10.1117 / 1.JBO.25.8.086005。
    Bruss, M L; Margolin, S B; Giri, S N;,Pharmacokinetics of orally administered pirfenidone in male and female beagles.，兽医药理学与治疗卷Vol.27，2004
    黄，H;陈，j z;Chou，B;Halladay，J S;肯尼，j r;洛杉矶，H;玛斯特，j c;Plise，E;Rudewicz，P j;robarge，k; Shin, Y; Wong, S; Zhang, C; Khojasteh, S C;,Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor.，Xenobiotica;生物系统中外国化合物的命运Vol.39，2009
    Petersson C, Papasouliotis O, Lecomte M, Badolo L, Dolgos H.,Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery, Xenobiotica. 2020 Mar;50(3):270-279. doi: 10.1080/00498254.2019.1625084. Epub 2019 Jun 19.
    Hayes Aw，Pressman P，Moser P，Soares-Da-Silva P.，Regulatory safety pharmacology evaluation of BIA 10-2474, J Pharmacol Toxicol Methods. 2020 Mar-Apr;102:106677. doi: 10.1016/j.vascn.2020.106677. Epub 2020 Jan 22.
    文卡塔萨布拉曼尼亚R,柯林斯助教,LJ莱斯科,Mettetal JT, Trame MN.,Semi-mechanistic modelling platform to assess cardiac contractility and haemodynamics in preclinical cardiovascular safety profiling of new molecular entities, Br J Pharmacol. 2020 Aug;177(15):3568-3590. doi: 10.1111/bph.15079. Epub 2020 Jun 18.
    Mitchell, Andrea Z; McMahon, Carrie; Beck, Tom W; Sarazan, R Dustan;,Sensitivity of two noninvasive blood pressure measurement techniques compared to telemetry in cynomolgus monkeys and beagle dogs.，药理毒理学方法杂志Vol.62，
    Wang T, Babusis D, Park Y, Niu C, Kim C, Zhao X, Lu B, Ma B, Muench RC, Sperger D, Ray AS, Murakami E.,肝积累的物种差异和核苷酸前药Sofosbuvir的代谢, Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.
    Guth, Brian D; Chiang, Alan Y; Doyle, Jennifer; Engwall, Michael J; Guillon, Jean-Michel; Hoffmann, Peter; Koerner, John; Mittelstadt, Scott; Ottinger, Sean; Pierson, Jennifer Beck; Pugsley, Michael K; Rossman, Eric I; Walisser, Jacqueline; Sarazan, R Dustan,对犬心脏尿液药物诱导变化的评价，由HESI赞助的财团结果。药理毒理学方法杂志Vol.75，
    官方药理学与治疗股份协会Vol.34 ,,The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog., The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog.
    Takahashi, Ryan H; Chang, Jae H; Pang, Jodie; Liang, Xiaorong; Ma, Shuguang;,Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study., Drug metabolism letters Vol.13, 2019

    毒理学

    Petruska，Janet M;remick，Amera K;莱吉恩，丁基;Vezina，Mark;罗宾逊，基思;马丁的Bussières;吉尔格，Brian C;Dubielzig，Richard R;，A Transient Developmental Background Finding in the Retina Observed in Neonatal Dogs in Juvenile Toxicology Studies., Toxicologic pathology Vol.47, 2019
    霍尔森，j f;树桩，d g;Pearce，L B;沃森，r e;DESUSSO，J M;，Absence of developmental toxicity in a canine model after infusion of a hemoglobin-based oxygen carrier, Implications for risk assessment. Reproductive toxicology (Elmsford, N.Y.) Vol.52, 2015
    Miller, G K; Valerio, M G; Pino, M V; Larson, J L; Viau, A; Hamelin, N; Labbé, R; Banks, C M;,Chronic effects of the novel glucocorticosteroid RPR 106541 administered to beagle dogs by inhalation., Toxicologic pathology Vol.28,
    Byrd, Richard A; Blackbourne, Jamie L; Knadler, Mary Pat; Schultze, Albert E; Vahle, John L;,Chronic Toxicology Studies of Basal Insulin Peglispro in Rats and Dogs，一种新颖的聚乙二醇化胰岛素LISPRO模拟，延长了持续时间的作用。毒理学病理Vol.45,2017
    Mitsuishi, Mikio; Oshikata, Takafumi; Kumabe, Shino; Kobayashi, Azusa; Katoku, Koshiro; Kanno, Takeshi; Hamamura, Masao; Tsuchitani, Minoru,Histological dermal changes caused by preparation and application procedures in percutaneous dose toxicity studies in dogs, rabbits and rats., Journal of toxicologic pathology Vol.28, 2015
    Bodié, Karen; Decker, Joshua H;,Incidental histopathological findings in hearts of control beagle dogs in toxicity studies., Toxicologic pathology Vol.42, 2014
    Kerr, Janet S; Galloway, Sheila; Lagrutta, Armando; Armstrong, Michael; Miller, Thomas; Richon, Victoria M; Andrews, Paul A;,Nonclinical safety assessment of the histone deacetylase inhibitor vorinostat., International journal of toxicology Vol.29,
    Watanabe, Dai; Nakara, Hiromi; Akagi, Keisuke; Ishii, Toshiya; Mizuguchi, Hiroyasu; Nagashima, Yoshikazu; Okaniwa, Azusa;,Oral glucose tolerance test and determination of serum fructosamine level in beagle dogs., The Journal of toxicological sciences Vol.29, 2004
    Hardisty JF, Harris SB, Hayes WA, Weber K.,Oral repeated-dose toxicity studies of BIA 10-2474 in beagle dogs, Regul Toxicol Pharmacol. 2020 Mar;111:104555. doi: 10.1016/j.yrtph.2019.104555. Epub 2019 Dec 23.
    哈哈尔，詹姆斯e;Sadgrove，Matthew P;Pacyniak，Erik;LEED，Marina G D;Weber，Waylon M;Doyle-eisele，Melanie;Guilmette，Raymond A;AGHA，Bushra J;Susick，Robert L;Mumper，Russell J; Jay, Michael,Orally administered DTPA di-ethyl ester for decorporation of (241)Am in dogs: Assessment of safety and efficacy in an inhalation-contamination model., International journal of radiation biology Vol.91, 2015
    Katavolos P, Cain G, Farman C, Romero FA, Magnuson S, Ly JQ, Choo EF, Katakam AK, Andaya R, Maher J.,临床前安全评价的一个高度Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs, Toxicol Pathol. 2020 Apr;48(3):465-480. doi: 10.1177/0192623319898469. Epub 2020 Mar 3.
    Cass L, Murray A, Davis A, Woodward K, Albayaty M, Ito K, Strong P, Ayrton J, Brindley C, Prosser J, Murray J, French E, Haywood P, Wallis C, Rapeport G.,Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent，pharmacol res持洞穴。2021 2月4日（1）：E00690。DOI：10.1002 / PRP2.690。
    Niven，Ralph;林克，马里恩伦;moutvic，罗纳德;吉布斯，赛斯;布里斯科，水晶;拉夫，霍华德;，在丙烯环孢霉素的安全性和毒理学glycol after 9-month aerosol exposure to beagle dogs., Journal of aerosol medicine and pulmonary drug delivery Vol.24, 2011
    Spence, S; Soper, K; Hoe, C M; Coleman, J;,心率纠正的QT Qt Qt间隔的意识形犬：一种基于协方差分析的公式。, Toxicological sciences : an official journal of the Society of Toxicology Vol.45, 1998