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    Cellular therapies

    Brott，David A;凯特汀，安妮;托马斯，荒地;迈克尔·劳顿;蒙哥马利，罗伯特·Richardson，Rudy J;响亮，Calvert S;，von Willebrand因子和von Willebrand因子肽在血管内皮细胞活化，扰动和/或损伤模型中的吞噬。，毒理学病理Vol.42,2014
    Applefeld WN, Wang J, Sun J, Pockros BM, Solomon SB, Feng J, Risoleo T, Cortés-Puch I, Gouél-Cheron A, Klein HG, Natanson C.,In canine bacterial pneumonia circulating granulocyte counts determine outcome from donor cells，输血。2020 APR; 60（4）：698-712。DOI：10.1111 / TRF.15727。EPUB 2020 2月22日。
    Doi, Takuya; Tomonari, Yuki; Kawasako, Kazufumi; Yamada, Naoaki; Tsuchitani, Minoru;,Lymphocytic adrenal medullitis and lymphocytic thyroiditis in a laboratory beagle dog.，2017年兽医医学科学Vol.79
    vrecenak，杰西D;Pearson，Erik G;Todorow，Carlyn A;李，海英;约翰逊，标记P;片状，艾伦W;子宫造血细胞移植后移植物与宿主病的临床前犬模型。，血液和骨髓移植的生物学：美国血液和骨髓移植学会杂志Vol.24，2018
    vrecenak，杰西D;Pearson，Erik G;桑德，马修T;Todorow，Carlyn A;李，海英;adru，Antoneta;布塔蒂，三等教育;佩兰托，威廉H;约翰逊，标记P;片状，艾伦W;Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation., Blood Vol.124, 2014
    麦吉尔，乔迪L;nair，arathy d s;程，川敏;rusk，rachel a;Jaworski，Deborah C;甘塔，罗马r;，Vaccination with an Attenuated Mutant of Ehrlichia chaffeensis Induces Pathogen-Specific CD4+ T Cell Immunity and Protection from Tick-Transmitted Wild-Type Challenge in the Canine Host, PloS one Vol.11, 2016

    General studies

    Rossman Ei，Cool F，Cordes J，Dhuyvetter D，Doyle JM，Friedrichs GS，Guth B，Neradilek MB，Parish St，Pierson JB，Polissar N，Tang HM。，EnocarducoGraphic和血液动力学指数在遥测的比格犬犬同时评估：HESI-Suponsored跨公司评估，J药狼毒剂方法。2020 Sep;105:106897. doi: 10.1016/j.vascn.2020.106897. Epub 2020 Jul 12.
    olías-molero艾，莫伦多，普罗兰MJ，Jiménez-antónMD，Day Mj，Domínguezm，Alunda JM。，Infection of dogs by Leishmania infantum elicits a general response of IgG subclasses，SCI批准。2020年11月2日; 10（1）：18826。DOI：10.1038 / S41598-020-75569-6。
    Uchida，Mitsuhiro;ITO，fumi;Tsuchiya，Toshiyuki;Shoji，Yoko;Kurosawa，Toru;，小猎犬犬的新型表型，其特征在于皮肤反应对皮肤肥大细胞脱粒的化合物48/80。，实验动物Vol.64,2015

    Ocular studies

    Duriairaj，Chandrasekar;沉，杰;凯瑟鲁克，Madhu;，基于基于的平移药代动力学 - 药效模型预测青光眼或眼高血压患者药物的眼压降低效果。，制药研究Vol.31，2014
    李，苏珊;布克，詹姆斯;沉，杰;Almazan，Alexandra;奥里拉，Werhner;哈尔斯，帕特里克;张，简;李华江;struble，克雷格;米勒，保罗e; Robinson, Michael R,Bimatoprost sustained-release intracameral implant reduces episcleral venous pressure in dogs.，兽医眼科Vol.21，2018
    Gronkiewicz, K M; Giuliano, E A; Kuroki, K; Bunyak, F; Sharma, A; Teixeira, L B C; Hamm, C W; Mohan, R R;,狗体内角膜纤维化模型的新型发展。, Experimental eye research Vol.143, 2016
    Gronkiewicz, Kristina M; Giuliano, Elizabeth A; Sharma, Ajay; Mohan, Rajiv R;,Effects of topical hyaluronic acid on corneal wound healing in dogs: a pilot study.，兽医眼科vol.20，2017年
    Mowat，Freya M;聪明，伊丽莎白;哦，安妮;福斯特，Melanie L，在使用无声的取代刺激的狗的杆，短波长和长/中波长锥反应的体内电静脉分化。，实验性眼睛研究Vol.185,2019
    密封，詹妮弗r;罗宾逊，迈克尔罗;布克，詹姆斯;Bejanian，码头;Coote，Michael;Attar，Mayssa;，Intracameral Sustained-Release Bimatoprost Implant Delivers Bimatoprost to Target Tissues with Reduced Drug Exposure to Off-Target Tissues., Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Vol.35,
    Chung, Jou-Ku; Spencer, Elizabeth; Hunt, Matthew; McCauley, Thomas;,小纤维兔李生士匍匐的眼部分布及药代动力学。，官方药理学与治疗股份协会Vol.34，
    Mowat，F M;gornik，k r;Dinculescu，A;Boye，S L;haaswirth，w w;Petersen-Jones，S M;Bartoe，J T;，Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach., Gene therapy Vol.21, 2014

    药理

    Vick, Andrew; Wolff, Ronald; Koester, Alan; Reams, Rachel; Deaver, Daniel R; Heidel, Shawn,6个月的吸入研究表征人胰岛素吸入粉（HIIP）的毒性，药代动力学和药效学术语。，气溶胶医学杂志：官方杂志中国医学艾滋病，2007年第207号
    Kendrick J，Stow R，Ibbotson N，adin-Tetdey G，Murphy B，Bailey G，Miller J，Helleberg H，Finderup Grove M，ØvlisenK，汉森JJ。，A novel welfare and scientific approach to conducting dog metabolism studies allowing dogs to be pair housed, Lab Anim. 2020 Dec;54(6):588-598. doi: 10.1177/0023677220905330. Epub 2020 Feb 16.
    Marier, J F; Beaudry, F; Ducharme, M P; Fortin, D; Moreau, J P; Massé, R; Vachon, P;,内毒素重复施用后飞蝇犬阿莫西霉素的药代动力学研究。，兽医药理学与治疗卷第24卷，2001年
    玲，翔;吴，文杰;樊东粉丝;徐，赵;廖，建议;富人，Laurie J;黄，瑞伊 - 是的;伊丽莎白A;王，新疆;李，冯志，ABCG2非底物抗癌剂FL118靶向耐药性癌症干细胞，克服人类胰腺癌的治疗抵抗力。, Journal of experimental & clinical cancer research : CR Vol.37, 2018
    Budachetri K，Teymournejad O，Lin M，Yan Q，Mestres-Villanueva M，Brock Gn，Rikihisa Y.，Ehrlichia的入学蛋白是一种针对蜱传播人单核细胞的新疫苗候选者，MBIO。2020年7月28日; 11（4）：E00895-20。DOI：10.1128 / MBIO.00895-20。
    贝尔德，西奥多j;Aulbach，亚当;odonohue，凯尔P;yoder，约书亚d;道尔顿，吉尔A;Gauvin，David V;后退ground variability in standard clinical pathology biomarkers in beagle dogs instrumented with chronic indwelling telemetry devices., Journal of pharmacological and toxicological methods Vol.69,
    Ooms, Tara G; Way, Holly L; Bley, John A;,序列静脉切开术对实验室比例进行的临床和血液学作用。, Contemporary topics in laboratory animal science Vol.43, 2004
    Roberts A，Grafton G，Powell Ad，Brock K，Chen C，谢D，Huang J，Liu S，Cooper AJ，Brady Ca，Qureshi O，Stamataki Z，Manning DD，Moore Na，Sargent BJ，Guzlo Pr，Barnes NM。，CSTI-300（SMP-100）;一种新的5-HT（3）受体部分激动剂，潜力可治疗肠综合征或癌综合征的肠综合征患者，J pharmacol exp ther。2020 APR; 373（1）：122-134。DOI：10.1124 / jpet.119.261008。EPUB 2020 2月26日。
    Mitchell, Sheila M; Zajac, Anne M; Charles, Sam; Duncan, Robert B; Lindsay, David S;,Cystoisospora canis Nemeséri, 1959 (syn. Isospora canis), infections in dogs: clinical signs, pathogenesis, and reproducible clinical disease in beagle dogs fed oocysts.，寄生虫学杂志Vol.93，2007
    Wilson, James P; Cobb, Ronald R; Dungan, Nathanael W; Matthews, Laura L; Eppler, Bärbel; Aiello, Kenneth V; Curtis, Shiro; Boger, Teannetta; Guilmette, Raymond A; Weber, Waylon; Doyle-Eisele, Melanie; Talton, James D;,通过在比猎犬犬的新型口服施用的二亚乙基三胺丙二酸酯（DTPA）配方来装饰系统分布的亚美。，健康物理卷108,2015
    Dhollander, Aad; Malone, Amanda; Price, James; Getgood, Alan;,比格犬膝关节软骨体积和表面积的测定, a pilot study. Journal of experimental orthopaedics Vol.4, 2017
    沉J，Moats Ra，Pollack Ha，Robinson Mr，Attar M.，Distribution of (14)C-Latanoprost Following a Single Intracameral Administration Versus Repeated Topical Administration，眼科醇。2020年12月9日（4）：929-940。DOI：10.1007 / S40123-020-00285-3。EPUB 2020 8月1日。
    Houle, Christopher D; Finch, Gregory L; Mauthe, Robert J; Potter, David M; Walisser, Jacqueline A; Gardner, Iain B; DeWit, Robert H;,LERIVIRIN对犬和啮齿动物甲状腺功能的影响。，毒理学病理Vol.42,2014
    Borron, Stephen W; Stonerook, Michael; Reid, Frances,Efficacy of hydroxocobalamin for the treatment of acute cyanide poisoning in adult beagle dogs., Clinical toxicology (Philadelphia, Pa.) Vol.44 Suppl 1, 2006
    克雷梅勒，约翰j;票据，安德鲁j;汉塔纳尔·汉克;陈，肝;梅尔，威廉A;osinski，标志a;Foley，C迈克尔;，使用夹套外部遥测 - 血压（Jet-BP）评估狗的心血管变化的评估施用三种阳性控制。，药理毒理学方法杂志Vol.75，
    Richards D，Bamford M，Liefaard L，Haque N，Lewis G，Storey J，Fernando D，Kumar S，Thompson D，Holmes DS。，Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap，Br J pharmacol。2020年4月; 177（8）：1853-1864。DOI：10.1111 / BPH.14956。EPUB 2020 2月11日。
    李，大卫的H;Pai，Y;辛，史蒂夫;金，D H;，纳米尺寸的磷酸钙颗粒的微观结构，物理性质和骨再生效应。, Materials science & engineering. C, Materials for biological applications Vol.58, 2016
    高地，jaclyn n;莫里斯，帕特里克j;Zanos，Panos;Lovett，杰奎琳;盖姆塔;王，艾米q;讽刺，卡洛斯A;托马斯，克雷格j;Moaddel，Ruin;古尔德，托德D;，鼠标，大鼠和狗生物利用度（2R，6R） - 羟基炔胺的小鼠口腔抗抑郁效果。，精神医学杂志（牛津，英国）Vol.75，2018
    Shin HW，Kim Je，Park YJ。，Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs, Pharmaceutics. 2021 Jan 6;13(1):E63. doi: 10.3390/pharmaceutics13010063.
    沉J，罗宾逊先生，Struble C，Attar M.，Nonclinical Pharmacokinetic and Pharmacodynamic Assessment of Bimatoprost Following a Single Intracameral Injection of Sustained-Release Implants，译音。2020 3月20日; 9（4）：20。DOI：10.1167 / TVST.9.4.20。黯然聚映2020 3月
    Mudie DM, Stewart AM, Biswas N, Brodeur TJ, Shepard KB, Smith A, Morgen MM, Baumann JM, Vodak DT.,Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole; In Vivo and In Vitro Assessment，mol pharm。2020年12月7日; 17（12）：4463-4472。DOI：10.1021 / ACS.MOLPRAMASEUT.0C00471。EPUB 2020 SEP 4。
    Cekanova M，Pandey S，Olin S，Ryan P，Stokes Je，Hecht S，Martin-Jimenez T，Uddin MJ，Marnett Lj。，Pharmacokinetic characterization of fluorocoxib D, a cyclooxygenase-2-targeted optical imaging agent for detection of cancer，j生物选择。2020 8月; 25（8）：086005。DOI：10.1117 / 1.JBO.25.8.086005。
    Bruss, M L; Margolin, S B; Giri, S N;,Pharmacokinetics of orally administered pirfenidone in male and female beagles.，兽医药理学与治疗卷Vol.27，2004
    黄，H;陈，j z;Chou，B;Halladay，J S;肯尼，j r;洛杉矶，H;玛斯特，j c;Plise，E;Rudewicz，P j;robarge，k; Shin, Y; Wong, S; Zhang, C; Khojasteh, S C;,Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor.，Xenobiotica;生物系统中外国化合物的命运Vol.39，2009
    Petersson C, Papasouliotis O, Lecomte M, Badolo L, Dolgos H.,Prediction of volume of distribution in humans: analysis of eight methods and their application in drug discovery, Xenobiotica. 2020 Mar;50(3):270-279. doi: 10.1080/00498254.2019.1625084. Epub 2019 Jun 19.
    Hayes Aw，Pressman P，Moser P，Soares-Da-Silva P.，Regulatory safety pharmacology evaluation of BIA 10-2474，J药狼毒剂方法。2020 3月4月; 102：106677。DOI：10.1016 / J.Vascn.2020.106677。EPUB 2020 1月22日。
    Venkatasubramanian R，Collins Ta，Lesko LJ，Metetal JT，Trame Mn。，半机械模型平台评估新分子实体临床前心血管安全性探讨心脏收缩力和血流动力学，Br J pharmacol。2020 Aug;177(15):3568-3590. doi: 10.1111/bph.15079. Epub 2020 Jun 18.
    米切尔，安德里亚Z;麦克马蒙，嘉莉;贝克，汤姆w;Sarazan，旧式;与猴子猴子和比格犬遥遥衡相比，两种非血压测量技术的敏感性。，药理毒理学方法杂志Vol.62，
    Wang T, Babusis D, Park Y, Niu C, Kim C, Zhao X, Lu B, Ma B, Muench RC, Sperger D, Ray AS, Murakami E.,肝积累的物种差异和核苷酸前药Sofosbuvir的代谢, Drug Metab Pharmacokinet. 2020 Jun;35(3):334-340. doi: 10.1016/j.dmpk.2020.04.333. Epub 2020 Apr 16.
    Guth, Brian D; Chiang, Alan Y; Doyle, Jennifer; Engwall, Michael J; Guillon, Jean-Michel; Hoffmann, Peter; Koerner, John; Mittelstadt, Scott; Ottinger, Sean; Pierson, Jennifer Beck; Pugsley, Michael K; Rossman, Eric I; Walisser, Jacqueline; Sarazan, R Dustan,对犬心脏尿液药物诱导变化的评价，由HESI赞助的财团结果。药理毒理学方法杂志Vol.75，
    官方药理学与治疗股份协会Vol.34 ,,The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog., The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog.
    高桥，瑞安H;张，jae h;庞，朱迪;梁，小荣;马，曙光;Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study.，药物代谢字母第13号，2019年

    毒理学

    Petruska，Janet M;remick，Amera K;莱吉恩，丁基;Vezina，Mark;罗宾逊，基思;马丁的Bussières;吉尔格，Brian C;Dubielzig，Richard R;，少年毒理学研究中的新生犬视网膜的瞬态发育背景。, Toxicologic pathology Vol.47, 2019
    霍尔森，j f;树桩，d g;Pearce，L B;沃森，r e;DESUSSO，J M;，Absence of developmental toxicity in a canine model after infusion of a hemoglobin-based oxygen carrier, Implications for risk assessment. Reproductive toxicology (Elmsford, N.Y.) Vol.52, 2015
    Miller, G K; Valerio, M G; Pino, M V; Larson, J L; Viau, A; Hamelin, N; Labbé, R; Banks, C M;,通过吸入给予比格犬的新型糖皮质激素RPR 106541的慢性效应。, Toxicologic pathology Vol.28,
    拜尔德，理查德A;Blackbourne，Jamie L;骑马者，玛丽帕特;舒尔泽，艾伯特e;Vawle，John L;，Chronic Toxicology Studies of Basal Insulin Peglispro in Rats and Dogs，一种新颖的聚乙二醇化胰岛素LISPRO模拟，延长了持续时间的作用。毒理学病理Vol.45,2017
    Mitsuishi, Mikio; Oshikata, Takafumi; Kumabe, Shino; Kobayashi, Azusa; Katoku, Koshiro; Kanno, Takeshi; Hamamura, Masao; Tsuchitani, Minoru,Histological dermal changes caused by preparation and application procedures in percutaneous dose toxicity studies in dogs, rabbits and rats., Journal of toxicologic pathology Vol.28, 2015
    博登，凯伦;甲板，约书亚H;，杂志毒性研究中的杂交组织病理学发现。，毒理学病理Vol.42,2014
    Kerr, Janet S; Galloway, Sheila; Lagrutta, Armando; Armstrong, Michael; Miller, Thomas; Richon, Victoria M; Andrews, Paul A;,组蛋白脱乙酰化酶抑制剂Vorinostat的非临床安全评估。, International journal of toxicology Vol.29,
    Watanabe, Dai; Nakara, Hiromi; Akagi, Keisuke; Ishii, Toshiya; Mizuguchi, Hiroyasu; Nagashima, Yoshikazu; Okaniwa, Azusa;,Oral glucose tolerance test and determination of serum fructosamine level in beagle dogs.，毒理学科学杂志Vol.29，2004
    难以努力的JF，Harris SB，Hayes Wa，Weber K.，Oral repeated-dose toxicity studies of BIA 10-2474 in beagle dogs，法调节毒药药物。2020 Mar; 111：104555。DOI：10.1016 / J.YRTPH.2019.104555。EPUB 2019年12月23日。
    哈哈尔，詹姆斯e;Sadgrove，Matthew P;Pacyniak，Erik;LEED，Marina G D;Weber，Waylon M;Doyle-eisele，Melanie;Guilmette，Raymond A;AGHA，Bushra J;Susick，Robert L;Mumper，Russell J; Jay, Michael,Orally administered DTPA di-ethyl ester for decorporation of (241)Am in dogs: Assessment of safety and efficacy in an inhalation-contamination model.，国际辐射生物学杂志Vol.91,2015
    Katavolos P，Cain G，Farman C，Romero Fa，MagnUson S，Ly JQ，Choo EF，Katakam Ak，Andaya R，Maher J.，临床前安全评价的一个高度Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs, Toxicol Pathol. 2020 Apr;48(3):465-480. doi: 10.1177/0192623319898469. Epub 2020 Mar 3.
    Cass L, Murray A, Davis A, Woodward K, Albayaty M, Ito K, Strong P, Ayrton J, Brindley C, Prosser J, Murray J, French E, Haywood P, Wallis C, Rapeport G.,PC945的安全和非临床和临床药代动力学，一种新型吸入三唑抗真菌剂，pharmacol res持洞穴。2021 2月4日（1）：E00690。DOI：10.1002 / PRP2.690。
    niven，拉尔夫;林克，马里恩伦;moutvic，罗纳德;吉布斯，赛斯;布里斯科，水晶;拉夫，霍华德;，9个月气溶胶暴露于比赛犬丙二醇中环孢菌素的安全性和毒理学。, Journal of aerosol medicine and pulmonary drug delivery Vol.24, 2011
    Spence, S; Soper, K; Hoe, C M; Coleman, J;,心率纠正的QT Qt Qt间隔的意识形犬：一种基于协方差分析的公式。, Toxicological sciences : an official journal of the Society of Toxicology Vol.45, 1998