Positive : Insights

The quality of research and welfare of laboratory animals greatly depends on the competence of those caring for them humanely and responsibly. That is why a comprehensive training program is vital to all employees in any laboratory animal care setting. Such programs help ensure employees are qualified for their jobs and are complying with federal regulatory policies.

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In this blog on bridging studies, we provide general best-practices relevant to oncology bridging studies, including basic study design considerations and insights that are the culmination of many years of hands-on experience by Envigo experts.

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Manual surgical monitoring techniques can be tedious for lab technicians as well as animals, given the multiple welfare checks needed per day plus the need for workers to update records accordingly. Further complicating matters, manual monitoring is generally done during daytime work hours, which causes researchers to miss out on valuable nighttime data points and activities. Fortunately, laboratories around the globe have a new tool at their disposal: implantable射频识别（RFID）微芯片。这一创新技术监控啮齿动物的坎e cage temperature and activity, “hands-free.”

使用RFID Microchips，现在可以在非侵入性，实时，连续的方式中监测实验室动物，同时单独或分组。在最近的一项五天的研究中，我们的Envigo团队与技术公司统一信息设备合作，试图raybetAPP增强心脏手术模型的前手术和后手术监测，并改善动物福利。

Six groups of rats and six groups of mice were implanted with standard RFID microchips via intraperitoneal injection. Rodents were assigned to either anMI.要么TACgroup and housed in one cage per study group. A wealth of data was generated from this study, bringing to light the many ways RFID technology can provide for more effective animal monitoring.

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分子化合物的临床前评价和测试潜在癌症治疗的治疗方法往往依赖于癌细胞系的生物医学研究。选择最合适的oncology cell lineto support an experimental design and drug development strategy requires careful consideration of a number of factors to ensure the research provides robust results that can translate from体外to体内最终进入诊所。

Peer-reviewed publications serve as an important component of the pre-planning process to stay up-to-date on the most current literature and findings about results generated from oncology cell lines. These references help researchers compare the advantages and drawbacks of using certain preclinical oncology models, understand potential risks and make more informed decisions in selecting a cell line for their preclinical studies.

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69.^th美国实验室科学协会（AALAS）国家会议最近在马里兰州巴尔的摩举行。一个论坛，致力于学术界，研究机构，政府组织和商业公司的代表们致力于实验动物的人文护理和治疗，从而聚集在一起享受一系列科学讲座，海报会话和展品。代表们还收到了最新的行业新闻和见解，包括我们已经总结为关键的监管机构的更新。

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使用新的研究HSD：SpragueDawley®SD®大鼠证实使用这种应变作为有价值的毒理学模型。多年来，这种菌株已被用于许多领域，例如生殖内分泌，毒理学，肿瘤学，心脏病和神经科学。

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饮食在实验研究中继续成为忽略的变量，影响生殖，生长和疾病，影响实验室动物的实验性操纵的反应。

Given thatreproducibility是对实验科学的行为和验证的关键原则，如何确保您的实验室饮食不会过度影响您的经验数据的结果和结论？

To answer this question, let’s discuss the function of a diet as a research tool and examine some of the key considerations in choosing the most optimal diet for your study’s needs.

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研究行业越来越依赖于改善动物福利的新技术和技术。随着纸质系统可能导致访问和准确性的问题，改善有限，而电子文件面临跟踪和遵守的挑战。我们一直专注于减少动物用法，并通过使用创新技术来减少3RS - 更换，改进和减少，通过使用外科医生的熟练来说，跟踪模型的手术，我们想与您分享我们的调查结果。了解该系统及其改善外科绩效的策略 - 和动物福利。

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TheR2G2.^®老鼠有可能帮助您在调查癌症疗法中打破新的地面。在最近的两项研究中，在整体存活和体重变化方面，这种模型耐受性的护理化疗和雌激素补充剂。以下是这种鼠标模型可以作为临床前人肿瘤异种移植研究的优秀宿主的五个原因。

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The selection of your animal model for toxicity and carcinogenicity testing plays an essential role in the accuracy of your study findings. Our researchers recently completed a two-year study of 130 male and 130 femaleEnvigo RccHan®:WIST (Wistar Han®)老鼠并将它们与其他争吵进行比较大鼠（例如，Sprague-Dawley®，Fischer 344）。Here, we share the results of the study.

The results provided insights on how Wistar Han provided numerous advantages, such as smaller body size, higher rates of survival and lower tumor/lesion incidence, as compared toCRL:CD®(SD) (CD)大鼠模型是前两年的研究的主题。

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