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临床前研究的质量是诊所成功翻译新药的关键。这种质量的重要推动力是一个健康，精心管理，精确的动物殖民地。为了实现这一目标，需要致力和经验，成功统治于最先进的设施，技术和殖民地管理实践的专业知识，以及全面的健康和遗传监测协议。研究人员如何确保灵活地访问可靠的这些高质量型号的供应？好吧，有一个艺术给它。

手术改性的动物模型在生物医学研究中发挥着关键作用，允许研究人员模仿人体状况的结构和功能性。然而，它只具有高度一致的标准化模型，研究人员可以自信他们的结果是可靠和可重复的。然而，维持完成精确的外科手术所需的技术技能是个人研究实验室的昂贵和耗时。因此，较差的研究团队越来越识别合同研究服务可以添加的价值。雷竞技LOL投注

很明显，个性化医学可以克服一定规模适合所有方法的一些局限性。在研究和实践中，越来越多地利用个性化药物。例如，它在生物标志物驱动的疗法的疗效研究中发挥了增加的作用，并通知治疗。

然而,对于该领域进一步发展,产品开发lopment of highly characterized pre-clinical models is essential in order to evaluate new targeted therapies and increase the scope of actionable mutations in the clinic. One such model, which helps bridge the preclinical research and the clinic, is the patient-derived xenografts (PDX) - where tissue from a patient's tumor is implanted into an immunodeficient or humanized mouse.

Using PDX models in research means that mutations seen in the clinic can be factored into the discovery pipeline from the earliest phases of a research program, in the preclinical setting. Andrew Brown, Global Product Manager at Envigo explains how this approach could transform the future of cancer treatments:

"PDX models allow us to work backwards from the clinic, so that development phases can target the mutations seen in patients. We can then go on to screen for those mutations in other patients, offering the opportunity to pair up an individual with the treatment that's been targeted to a true representation of their tumor."

有效的殖民地管理确保可重复的研究结果和遵守3R的原则。冷冻保存和Rederivation Services是满足这些标准的高效工具，但尚未广泛使用。Recent researchhas revealed that many laboratory professionals are unaware of the benefits of cryopreservation and rederivation for effective colony management, which may explain the variable uptake of these services across facilities.

Now that research is resuming following the difficulties posed by COVID-19, researchers are keenly aware of the need to consider proactive disaster-mitigation strategies within their colony management plans. With this additional focus in mind, cryopreservation and rederivation services are uniquely placed to bolster efficiency, embed 3R principles, and ensure research continuity in the face of unseen circumstances.

The shift in research priorities due to COVID-19 has required rapid adjustment across the biomedical sector. The speed and effectiveness of this response supports our current scientific understanding of the virus, and will eventually lead to the delivery of symptomatic treatments and preventative vaccines.

特别是，动物研究在全球搜索Covid-19的治疗或疫苗中至关重要。啮齿动物模型正在推进我们对病毒本身的理解，以及非人类灵长类动物的研究可以ensure the safety profile of potential therapies，在他们进行人体试验之前。

However, animal research organizations are experiencing the same COVID-19 related complications as any other industry. For those who provide the tools and services necessary for this research, it has been a prominent concern to ensure scientists continue to have access to what they need.

下面，我们突出了自大流行开始以来的一些方式的方式：

Why is the shortage in non-human primates such a serious issue for the scientific community?

Non-human primates (NHPs) are critical for clinical development pathways of new drug applications, but NHP suppliers are currently struggling to meet an unprecedented surge in global demand.

A国家健康研究所（NIH）2013年至2017年间授予的补助金透露，近一半的NIH资助调查人员报告难以获得足够数量的NHP或相关服务进行研究。这意味着包括研究启动和拨款扩展的广泛请求的临界延迟。这些是由拉伸的时间表驱动，并且在最初要求授予金额时，不可预见的成本增加。

Securing research funding is becoming increasingly difficult with the ever-growing competition across all disciplines worldwide vying for grant approval. For instance, the National Institutes of Health (NIH)invests nearly $42 billion in medical research every year. Eighty percent of that goes toward extramural research. That's roughly 50,000 competitive grants to 300,000+ researchers at more than 2,500 universities, medical schools, and other research institutions across the globe.

The NIH授予3,413奖励去年的研究机构中的167名。它是世界生物医学研究最大的单一资金来源。然而，这些数字建议调查人员的收到NIH批准的几率不到7％。以下是帮助科学家在确保赠款和其他资金方面成功的四个提示：

Lab rats and mice have been used for decades to make great medical advances, from HIV antiretrovirals to the flu vaccine. But there’s always been an interesting debate about which is the more useful animal model — the rat or the mouse.

随着冠状病病病原体的目前毁灭性出现，灵活的研究模型从未如此重要。让我们仔细看看辩论背后的故事，看看2020年是否确实是实验室大鼠的年份。

Immunodeficient rodents可以作为基础研究的宝贵部分，以帮助研究人员更好地了解免疫相关疾病和免疫应答。使用这些独特的模型在开发化疗，免疫疗法，生物学和生物学和CAR T-cell therapiesand even contributed to imaging techniques and personalized medicines.

虽然这些啮齿动物模型可以在研究中非常强大，但是他们可以理解地需要非常特别注意，保持健康状况，并降低可能脱轨研究结果的病原体和感染的风险。

本博客讨论雷竞技电竞官网雷电竞下载苹果app了免疫啮齿动物如何养育和携带，以及床上用品，富集，包装和运输的考虑，以确保这些啮齿动物的护理，他们需要在整个生活中保持健康。

致力于保护和改善人类，动物和植物生活的公司，企业和研究机构继续突破，了解影响它们的疾病的性质。